Impact of betel quid, tobacco and alcohol on three-stage disease natural history of oral leukoplakia and cancer: implication for prevention of oral cancer.

The natural history of the three-stage process from normal, oral leukoplakia to oral cancer in relation to betel quid chewing, smoking and drinking is rarely addressed. The aim of this study was to simultaneously quantify the effects of three risk factors on occurrence of oral leukoplakia and malignant transformation to oral cancer. A hospital-based case-control study design derived from three retrospective cohorts from 1988 to 1998 was conducted. A total of 74 oral cancer patients, 164 patients with oral leukoplakia and 187 controls were interviewed to collect information on their betel chewing, smoking and drinking habits. The effects of the three risk factors on the progression rates of the three-stage disease process were estimated using the three-state Markov model. Subjects who chewed betel quid were at greater risk of leukoplakia (adjusted odds ratio (OR) 17.7 (9.03-34.5)) but there was no significant effect on malignant transformation (OR 1.04 (0.61-1.76)). Smoking played a major role in the onset of leukoplakia (OR 4.26 (2.21-8.23)) but a minor role in malignant transformation (OR 1.36 (0.69-2.68)). Alcohol was positively associated with malignant transformation (OR 2.37 (1.47-3.82)) but unrelated to occurrence of leukoplakia (OR 0.76 (0.04-1.43)). We concluded that smoking and betel quid were two significant risk factors for the occurrence of leukoplakia, whereas alcohol was significantly responsible for malignant transformation.

Antibiotic usage in primary care units in Taiwan after the institution of national health insurance.

To understand antibiotic usage in primary care units in Taiwan after the institution of national health insurance, we collected all prescriptions for one week in March each year from 1996 to 1999 from out-patient clinics of randomly sampled public health stations located in various parts of Taiwan. We sampled 114 health stations with 40,891 patient-visits and 68,386 diagnoses made in 1996; 154 health stations were sampled with 53,992 patient-visits and 99,466 diagnoses in 1997; 166 health stations were sampled with 49,112 patient-visits and 96,161 diagnoses in 1998; and 162 health stations were sampled with 46,976 patient-visits and 93,641 diagnoses in 1999. The percentages of total patient-visits that resulted in antibiotic treatment were 14.2%, 12.5%, 14.1% and 13.0% in the four time periods, respectively. Among patient-visits, patient group under the age of 11 received the highest percentage of antibiotic treatment. Common cold was the most frequent diagnosis for which antibiotic was prescribed during the four time periods, accounting for 32.3% of total antibiotic prescriptions. Among patients with the diagnosis of common cold, 31.3% received antibiotic treatment, and the highest figure was among pediatric patients (<16 year of age). Penicillins, cephalosporins and macrolides were the most commonly prescribed classes of antibiotics. They accounted for 35.4%, 26.5% and 21.6% of all prescribed antibiotics in these four study periods. From this study, it was found that, after institution of the national health insurance system, antibiotics are still very commonly used in primary care units in Taiwan and still seem to be overused.

Risk factors for leukoplakia and malignant transformation to oral carcinoma: a leukoplakia cohort in Taiwan.

The effects of betel nut chewing, smoking and alcohol on the occurrence of leukoplakia and its malignant transformation to oral carcinoma were quantified in a leukoplakia cohort (n = 435) from one medical centre between 1988 and 1998 in Taiwan. Sixty oral carcinomas were ascertained in this cohort. A case-control study within the leukoplakia cohort was used to study, risk factors. Using the Weibull survival model, the incidence of malignant transformation of leukoplakia was shown to increase with follow-up years. After adjustment for other relevant risk factors, betel nut chewing (adjusted odds ratio (OR) = 4.59; 95% confidence interval (CI) 1.25-16.86) remained a significant risk factor for malignant transformation. Results from the case-control study showed that the adjusted odds ratios for betel nut chewing and smoking on the occurrence of leukoplakia were 17.43 (95% CI 1.94-156.27) and 3.22 (95% CI 1.06-9.78), respectively. Similar findings were observed when daily frequency and duration were taken into account. This implies that cessation of smoking may reduce by 36% leukoplakia cases, while elimination of betel nuts may prevent 62% of leukoplakia and 26% of malignant transformation to oral carcinoma in the underlying population.