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Org Biomol Chem
; 20(34): 6863-6868, 2022 08 31.
Article
in English
| MEDLINE
| ID: mdl-35971986
ABSTRACT
An environmentally benign, cost-effective and scalable process for the preparation of both the enantiomers of 3-hydroxytetrahydrofuran has been developed. pH-Controlled ring opening of enantiomerically pure epichlorohydrins with cyanohydrin is the key step of the process. The entire protocol does not require any column purification.