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Vopr Onkol ; 34(2): 200-4, 1988.
Article in Russian | MEDLINE | ID: mdl-3348011

ABSTRACT

Polyamines levels were studied in various tissue specimens obtained from high-leukemia AKR mice aged 12 months and less. Organ tissues of leukemic animals revealed increased levels of polyamines and changes in their profile. In symptomatic mice, this was matched by relevant morphologic changes. It is inferred that putrescine is a marker of latent leukemia development.


Subject(s)
Biomarkers, Tumor , Lymphoma/metabolism , Polyamines/biosynthesis , Animals , Brain Chemistry , Female , Kidney/metabolism , Liver/metabolism , Lung/metabolism , Male , Mice , Mice, Inbred AKR , Putrescine/biosynthesis , Spermidine/biosynthesis , Spermine/biosynthesis , Spleen/metabolism , Thymus Gland/metabolism
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