[Activity of lysosomal enzymes in cardiomyocytes, hepatocytes and blood in experimental diphtheritic intoxication]. / Aktivnost' lizosomnykh fermentov v kardiomiotsitakh, gepatotsitakh i krovi v dinamike éksperimental'noi difteriinoi intoksikatsii.

Non-sedimentable activity of N-acetyl-beta-D-galactosaminidase and beta-D-glucuronidase was studied in left and right ventricles of myocardium, in liver tissue and blood plasma of rabbits with experimental diphtheritic intoxication. Specific dynamics of the enzymatic activity was found during the diphtheritic intoxication, indicating that various mechanisms were involved in regulation of lysosomal membranes permeability under conditions of the disease.

[Protective lysosomal autoregulatory mechanism and its disorders in diphtheric intoxication]. / Zashchitnyi lizosomnyi samoreguliatornyi mekhanizm i ego narushenie pri difteriinoi intoksikatsii.

Diphterial intoxication was established in rabbits by means of bolus 1 DLM/kg intravenous injection of diphterial toxin. Different types of N-acetyl-beta-1)-galactosaminidase's activity were determined in lysosomal fraction which had been obtained after ultracentrifugation of the left and right ventricles' tissue of the heart. It has been found that the mechanism of fixation's reinforcement of this enzyme exists in lysosomes in case of increasing of its activity. This mechanism was damaged on the different stages of diphterial intoxication that influenced negatively the heart's contractility.

[Changes in the activity of lysosomal enzymes and in the indices of cardiac contractile function in experimental diphtheria poisoning in rabbits]. / Izmenenie aktivnosti fermentov lizosom i nekotorykh pokazatelei sokratitel'noi funktsii serdtsa pri éksperimental'noi difteriinoi intoksikatsii u krolikov.

Contractility of the heart ventricles and the activity of N-acetyl-beta-D-galactosaminiidase in fraction of lysosomes of this part of the heart were studied in rabbits with experimental diphtheritic intoxication. Three days after the onset of the process changes in the activity of the enzyme reached maximum and were expressed in increase of values indicating increased transfer of enzymes from the particles into the cytosol. At the same time, values which were evidence of fixation of the enzyme in the lysosomes reduced. Correlation analysis showed that intensified escape of enzymes into the cytoplasm led to weakening of heart contractile function.