ABSTRACT
Biologic action was studied of the silicon nitride powder with varying disperse composition. When producing and using the silicon nitride powder on an enlarged scale one must remember of its higher toxicity and fibrogenicity. There is a need of employing some method of determination of the submicroscopic aerosol disperse composition under industrial conditions.
Subject(s)
Air Pollutants, Occupational/toxicity , Silicon Compounds/toxicity , Aerosols , Air Pollutants, Occupational/administration & dosage , Animals , Dust/adverse effects , Lung/drug effects , Lung/pathology , Maximum Allowable Concentration , Particle Size , Powders , Silicon Compounds/administration & dosage , Time FactorsABSTRACT
Dust of mineral wool obtained from ferronickel slags was demonstrated to be capable of inducing moderate pneumofibrosis. Small contents of manganese, nickel, chrome and cobalt in the mineral wool particles necessitate further investigations for their probable mutagenic effect.
Subject(s)
Calcium Compounds/toxicity , Dust/adverse effects , Iron/toxicity , Nickel/toxicity , Silicates/toxicity , Animals , Blood-Air Barrier/drug effects , Lung/drug effects , Lung/pathology , Microscopy, Electron , Pulmonary Fibrosis/chemically induced , Pulmonary Fibrosis/pathology , Rats , Time FactorsABSTRACT
The authors investigated the activity of alkaline phosphatase, alanine- and aspartate-aminotransferases of the blood serum, mitochondria and postmitochondrial fraction of the liver in conditions of administration of mineral cotton from ferronickel slag. It was shown that 1 and 3 months after introduction of mineral cotton dust changes occurred in the activity of these enzymes. Restoration of these enzymes occurred 6 months after introduction of mineral cotton dust.
