Subject(s)
Immune Sera/administration & dosage , Liver Diseases/enzymology , Liver Regeneration , Liver/immunology , gamma-Globulins/administration & dosage , Animals , Carbon Tetrachloride Poisoning/enzymology , Carbon Tetrachloride Poisoning/therapy , Chronic Disease , Liver/enzymology , Liver/ultrastructure , Liver Diseases/therapy , Liver Function Tests , Male , Rats , Rats, Inbred StrainsSubject(s)
Adenosine Deaminase/blood , Alkaline Phosphatase/blood , Clinical Enzyme Tests , Hepatitis, Viral, Human/diagnosis , Nucleoside Deaminases/blood , Nucleotidases/blood , Biliary Tract Diseases/diagnosis , Diabetes Mellitus/diagnosis , Diagnosis, Differential , Enzyme Activation , Gastritis/diagnosis , Humans , Neoplasms/diagnosis , Peptic Ulcer/diagnosisSubject(s)
Carrier State/metabolism , Hepatitis B Surface Antigens/analysis , Hepatitis B/metabolism , Liver/metabolism , Adenosine Deaminase/blood , Bilirubin/metabolism , Carrier State/diagnosis , Chronic Disease , Clinical Enzyme Tests , Enzyme Activation , Hepatitis B/diagnosis , Humans , Transaminases/metabolismABSTRACT
Activity of alanine and aspartate aminotransferase, alkaline phosphatase, adenosine, desaminase and AMP-aminohydrolase was determined in rats in the process of the liver regeneration under acute and chronic lesion with CCl4. It is shown that under chronic lesion of the liver with CCl4, in contrast to the acute one, changes in the aminotransferase activity in blood serum are not expressed in the liver, the activity is essentially decreased. A steady increase was observed in the activity of adenosine desaminase, AMP-aminohydrolase and alkaline phosphatase in the liver and blood serum. It is concluded that the normal regenerative process is accompanied by short-term shifts of the enzymes activity in the liver and blood serum. The development of a chronic process results in a characteristic increase in the activity of adenosine desaminase, AMP-aminohydrolase and alkaline phosphatase in the liver and blood serum.
Subject(s)
Carbon Tetrachloride Poisoning/enzymology , Liver Regeneration , Liver/enzymology , AMP Deaminase/metabolism , Acute Disease , Adenosine Deaminase/metabolism , Alanine Transaminase/metabolism , Alkaline Phosphatase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Chronic Disease , RatsABSTRACT
After partial hepatoectomy of the rat normal liver a maximum three-fold increase in the activity of alkaline phosphatase is observed in the blood serum, on the second-third day, and by the 14th day becomes almost normal; the activity of adenosine desaminase, AMP-aminohydrolase and 5'-nucleotidase becomes 30-60% as high for one-two days. The activity of the alkaline phosphatase in the liver becomes four times as high and reaches normalcy by the sixth day. The activity of adenosine desaminase and AMP-aminohydrolase increases to a less extent for a fortnight. The activity of 5'-nucleotidase decreases in the first day, then rises and a fortnight later becomes normal. After partial hepatoectomy of the liver injured with deoxicholic acid the activity of all the enzymes in blood serum anr a longer period of time; in the 5'-nucleotidase activity there is no initial drop and its earlier subsequent increase is observed.
