[Effect of axoplasmic transport blocking and denervation on the activity and isomolecular spectra of some dehydrogenases in rat muscles]. / Vliianie blokirovaniia aksoplazmaticheskogo transporta i denervatsii na aktivnost' i izomolekuliarnye spektry nekotorykh degidrogenaz v myshtsakh krys.

Changes in the total activity and in the activity of isoenzyme forms of lactate dehydrogenase (EC 1.1.1.27), malate dehydrogenase (EC 1.1.1.37) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49) are found in rat musculus gastrocnemius two weeks after blocking axoplasmic transport evoked by the application of 0.05 M colchicine solution to the ischiatic nerve. They are identical to those observed in surgical denervation. The changes in the isomolecular forms of the enzyme permit considering that the cell metabolism is affected by the axoplasmatic transport.

[Effect of axoplasmic flow blockade on enzymic activities and components of the rat muscle adenylate system]. / Vliianie blokady aksoplazmaticheskogo toka na fermentativnye aktivnosti i komponenty adenilovoi sistemy myshts krys.

Proteolytic aspartate and alanine aminotransferase, beta-D-galactosidase, N-acetyl-beta-D-glucosaminidase activities, contents of phosphocreatine, AMP + IMP, ADP, ATP were studied in the rat musculi gastrocnemius after denervation and blockade of axoplasmic flow, the latter being caused by 0.05 M colchicin solution applied to the sciatic nerve. Two weeks after denervation and the axoflow disturbance all the indices (except the N-acetyl-beta-D-glucoseaminidase activity) showed uniform changes. A month following the colchicin blockade the phosphocreatine and adenylates contents became normal. A conclusion is made on significance of the axoplasmic flow as a factor performing the trophic function of the nervous system.