ABSTRACT
AIM: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N). MATERIALS AND METHODS: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day. RESULTS: Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients. CONCLUSION: Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Enalapril/therapeutic use , Hypertension/drug therapy , Administration, Oral , Adolescent , Adult , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Blood Pressure/drug effects , Diuretics , Drug Therapy, Combination , Enalapril/administration & dosage , Follow-Up Studies , Humans , Hydrochlorothiazide/administration & dosage , Hydrochlorothiazide/therapeutic use , Hypertension/diagnosis , Hypertension/physiopathology , Middle Aged , Safety , Severity of Illness Index , Sodium Chloride Symporter Inhibitors/administration & dosage , Sodium Chloride Symporter Inhibitors/therapeutic use , Treatment OutcomeABSTRACT
Described in the article is one of the forms of optimization of the instructional process in the postgraduation physician training--"business-like games". Highly skilled, competent position of the teacher who conducts a business-like game secures an active participation in learning of students, helps in opening the mind, broadening the outlook on the problem under consideration, gives much incentive to further independent work on the discussed issues.
Subject(s)
Education, Medical, Continuing/methods , Games, Experimental , Teaching/methods , Diagnosis, Differential , Humans , Problem Solving , UkraineABSTRACT
Altogether 64 patients with coronary heart disease (CHD) were examined using coronaroventriculography, bicycle ergometry with echocardiogram recorded at rest and in threshold exercise. During aortocoronary bypass surgery myocardial biopsies were taken from 20 patients. A correlation analysis of the morphofunctional state of the microcirculatory bed and changes in myocardial contractility showed that a decrease in myocardial contractility occurred in parallel with structural shifts.
Subject(s)
Cardiomyopathy, Dilated/physiopathology , Coronary Disease/physiopathology , Myocardial Contraction , Myocardium/ultrastructure , Adult , Cardiomyopathy, Dilated/etiology , Cardiomyopathy, Dilated/pathology , Coronary Disease/pathology , Hemodynamics , Humans , Male , Microscopy, Electron , Middle AgedABSTRACT
Echocardiography was used in the examination of 51 patients with chronic ischemic heart disease (IHD) without accompanying hypertension and congestive circulatory insufficiency. With gradual advancement of the disease, a significant increase in left-ventricular volumes during the systole and diastole was recorded as well as a decrease in the ejection fraction (IF) and velocity of circulatory shortening of the myocardial fibres (Vch) in slight variations of the stroke volume. The IF and Vch were the most characteristic indices for appraising the early manifestations of myocardial contractility disorders. The index of left-ventricular structure functioning intensity (SFI) was used to characterize the functional state of the heart muscle. In patients with a severe course of the disease, SFI was found to be reduced because of an increase in the myocardial mass. The developing damage hypertrophy, however, did not provide for full compensation of left-ventricular function and was attended by a reduction of the indices of contractility and pump function of the heart. This provides the grounds for the assumption that the reduction of SFI in patients with severe IHD is associated with exclusion of part of the myocardium involved in the pathological process from effective functioning.
