[The selenium content of the body in experimental animals and its effect on the functional biochemical status of the liver in toxic injury]. / Vmist selenu v orhanizmi eksperymental'nykh tvaryn i ioho vplyv na funktsional'no-biokhimichnyi stan pechinky pry toksychnomu ïï urazhenni.

Selenium content in organs and blood as well as the effect of diets with different selenium content on the functional and biochemical status of liver in toxic damage by tetrachloride carbon and ethyl alcohol was investigated on white male rats. Selenium content in the organism of experimental animals has been shown to undergo season fluctuations. Both tetrachloride carbon and ethyl alcohol have been shown to caise significant disturbances of functional and biochemical lever status at the background of selenium-deficient diet whereas selenium-enriched diet results in much less marked changes in the liver. These investigations provide grounds for considering selenium status in the organism with respect to preventing possible liver complications due to pathogenic factors.

[Antioxidant effectiveness in isoniazid-induced lesions of the liver]. / Effektivnost' antioksidantov pri porazhenii pecheni izoniazidom.

In male albino rats tocopherol acetate and sodium selenite were shown to be efficient in treatment of isoniazide-induced liver damage. The disturbances of secretion of bile, bile acids and bilirubin and excretion of cholesterol were less pronounced. A decrease of the activity of marker blood serum enzymes--alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase--also indicated the hepatoprotective effect of these drugs. The intensity of lipoperoxidation indicated by a decrease of lipid peroxidation indices in the liver and blood was diminished. Tocopherol acetate and sodium selenite increase the number of sulfhydryl groups but decrease the number of disulfide groups in these biosubstrates.

[Use of bioflavonoids to prevent the harmful action of tetracycline on the liver]. / Ispol'zovanie bioflavonoidov dlia profilaktiki otritsatel'nogo deistviia tetratsiklina na pechen'.

It was shown in experiments on male albino rats that the plant bioflavonoids flamin, flakumin and tanaflon had hepatoprotective properties in liver function impairment caused by tetracycline intoxication. This was evident from a significant improvement of biliary secretion, synthesis and secretion of bile acids and bile secretion of bilirubin and cholesterol not only in the animals untreated with tetracycline but also in the controls. A decrease in the activity of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the serum was indicative of the pronounced hepatoprotective effect of the bioflavonoids. They inhibited lipid peroxidation in the hepatocyte membranes evident from a decrease in the content of malonic dialdehyde and diene conjugates in liver homogenates. The antioxidant properties were especially pronounced in tanaflon. Correlation between lipid peroxidation, activity of the transferases and alkaline phosphatase and cholopoiesis both in tetracycline intoxication and in the prophylaxis and treatment with flamin, flakumin and tanaflon was shown.

[Synergistic effect of rifampicin on hepatotoxicity of isoniazid]. / O potentsiruiushchem deistvii rifampitsina na gepatotoksichnost' izoniazida.

It was shown in experiments on male albino rats that rifampicin potentiated the hepatotoxicity of isoniazid. As compared to the use of isoniazid alone, its combination with rifampicin resulted in a higher activity of transaminases and alkaline phosphatases and a higher rate of inhibition of biliary secretion and synthesis and excretion of bile acids, bilirubin and cholesterol with bile. Moreover, an increase was observed in the level of lipid peroxidation products of the hepatocyte membranes in liver homogenates and blood, which was indicative of an increased intensity of lipid peroxidation. The increased hepatotoxicity of isoniazid was evident from a more pronounced decrease in the number of sulfhydryl groups accompanied by an increase in the number of disulfide ones in the liver and blood. The authors suggest that potentiation of isoniazid hepatotoxicity under the action of rifampicin was due to its inducing activity with respect to the microsomal oxidation enzymes.

[Effect of ethyl alcohol on bile production and lipid peroxidation in tetracycline-induced liver lesions]. / Vliianie étilovogo spirta na zhelcheobrazovanie i perekisnoe okislenie lipidov pri porazhenii pecheni tetratsiklinom.

The experiments with male albino rats showed that in toxic doses tetracycline induced affections of the liver evident from activation of transferases and alkaline phosphatases in the blood serum, inhibition of bile secretion, synthesis and secretion of bile acids and excretion of bilirubin and cholesterol with the bile. Moreover, the content of the products of lipid peroxidation in liver homogenates increased. Acute intoxication with ethyl alcohol also induced hepatic disorders. However, they were less pronounced. The intoxication was accompanied by inhibition of cholopoiesis associated with increasing free radical oxidation of lipids. On combined use of tetracycline and ethyl alcohol no potentiation or summation of their hepatotoxicity was observed.

[Lipid peroxidation and bile formation in a paracetamol lesion of the liver]. / Sostoianie perekisnogo okisleniia lipidov i zhelcheobrazovaniia pri porazhenii pecheni paratsetamolom.

It has been demonstrated in experiments on male rats that liver injury induced by paracetamol is accompanied by inhibition of bile secretion and of the synthesis and secretion of bile acids, bilirubin elimination and cholesterol excretion with bile, by reduction in the cholate/cholesterol ratio. Activation of alanine-, aspartate aminotransferase and alkaline phosphatase of blood serum attests to a change in liver function. When administered in a toxic dose paracetamol induces lipid peroxidation of hepatocyte cell membranes. The correlation was established between lipid peroxidation, transaminases and alkaline phosphatase activity in blood serum and bile formation.