1.
Mol Gen Genet
; 186(4): 572-4, 1982.
Article
in English
| MEDLINE
| ID: mdl-6290848
ABSTRACT
To investigate the interaction of subunits A and B of DNA gyrase during DNA supercoiling, a Cour mutant of Escherichia coli was obtained and the effect of nalidixic acid on the supercoiling of DNA by wild-type and mutant enzymes was assayed. The enzyme of the Cour strain proved to be more sensitive to nalidixic acid than the wild-type DNA gyrase. Hence the mutation affecting the B subunit can also change the properties of the A subunit, which fact suggests that the two subunits of DNA gyrase are in contact during DNA supercoiling.
Subject(s)
DNA Topoisomerases, Type II/genetics , DNA, Superhelical/genetics , Enzyme Precursors/genetics , Escherichia coli/genetics , Mutation , DNA Topoisomerases, Type II/metabolism , DNA, Bacterial/genetics , Enzyme Precursors/metabolism , Phenotype
2.
Gen Comp Endocrinol
; 35(4): 355-9, 1978 Aug.
Article
in English
| MEDLINE
| ID: mdl-720809
Subject(s)
Chloramphenicol/pharmacology , Estrogens/biosynthesis , Ethidium/pharmacology , Mitochondria/drug effects , Progesterone/biosynthesis , Animals , Anura , Female , Gonadotropins, Equine/pharmacology , Mice , Mitochondria/metabolism , Oogenesis/drug effects , Organ Size/drug effects , Uterus/anatomy & histology
3.
Biochem Biophys Res Commun
; 37(6): 965-9, 1969 Dec 04.
Article
in English
| MEDLINE
| ID: mdl-4188261
