[Correlation between HLA antigens and immune status in dust-induced lung diseases in workers of machine-building industry]. / Vzaimosviaz' mezhdu antigenami sistemy HLA i sostoianiem immuniteta pri pylevoi patologii legkikh u rabochikh mashinostroitel'noi promyshlennosti.

Simultaneous study of immune state and HLA-testing was conducted for 73 patients with pneumoconiosis and 52 sufferers from dust bronchitis. The HLA antigens appeared to correlate with immune disorders in those diseases. The study revealed differences in the HLA antigens causing immune changes in pneumoconiosis and dust bronchitis. Those differences corresponded to differences between the markers of propensity to those diseases. Thus, the authors assume that formation of pneumoconiosis or dust bronchitis could depend on genetically determined variants of immune disorders.

[The immune system in dust-induced bronchitis]. / Immunnaia sistema pri pylevom bronkhite.

Studies of the immunity in 233 patients with dust-induced bronchitis (DIB), engaged in machine building, have revealed essential shifts in the T and B immunity systems, that were related to the severity and clinical features of the disease. The authors have set up the criteria for defining the normal range of values and the range of immunologic values characteristic of DIB; this helped detect the disordered immunity parameters in each of the examined patients. A method for the diagnosis of the immunity disorders in DIB patients is suggested, making use of just two characteristics, the per cent share of active T and B lymphocytes and their ratio, this essentially simplifying and accelerating the investigation.

[Characteristics of the ambulatory care of patients with complicated forms of dust-induced bronchitis]. / Osobennosti dispanserizatsii bol'nykh oslozhnnenymi formami pylevogo bronkhita.

The efficacy of follow-up was evaluated in 83 patients facing complicated dust bronchitis of 2 and 3 grades. An active follow-up group was treated by immunopotentiators in clinic every 3-4 months so as to prevent recurrences, while the passive follow-up group received the stationary treatment only once a year. Observations within 3 years showed a great efficiency of the active follow-up combined with the antirecurrence treatment given 3-4 times a year. Immune status was stressed to improve in connection with the clinical relief.

[Immune reactivity in pneumoconiosis and coniotuberculosis in machine builders]. / Immunologicheskaia reaktivnost pri pnevmokonioze i koniotuberkuleze u mashinostroitelei.

Immune status was examined in 231 patients facing pneumoconiosis and coniotuberculosis so as to observe a dependence on pneumoconiosis type (silicosis, electric welder's pneumoconiosis), severity of the process, activity of tuberculosis. Markedly changed T and B immunity, having already appeared at initial stage of the disease, were revealed. Those changes due to the tuberculosis activity were characterized by lymphocytosis, marked functional immaturity of T lymphocytes, depressed B lymphocytes count, elevated serum Ig level.

[Use of chlotazol as an immunomodulating agent in chronic bronchitis]. / Primenenie khlotazola v kachestve immunomoduliruiushchego sredstva pri khronicheskom bronkhite.

A positive immunomodulatory effect was found in chronic bronchitis patients examined immunologically before and after treatment including chlotazol. T- and B-cell immunity recovered, clinical condition of the patients improved. A combination of known antimicrobial and antiinflammatory effects with an uncovered immunomodulatory one made chlotazol a valuable modality in the treatment of chronic bronchitis associated with secondary immune deficiency.

[Laser therapy in dust bronchitis]. / Lazeroterapiia pri pylevom bronkhite.

Laser therapies of 43 dust bronchitis patients (4 cases in 1st stage and 39 cases in 2nd stage) were performed in comparison with routine therapeutic procedures of 28 patients (6 cases in 1st stage and 22 cases in 2nd stage). 14 acupuncture points were selected. A good therapeutic effect was attained in 16.3% sample group and 7.1% control group patients, satisfactory results--in respectively 58% and 42.9% cases, insignificant results--in 25.6% and 50% cases. Along with the favourable therapeutic effect, a positive influence of laser therapy on the immune system was established, particularly on the immunity T-system, in dust bronchitis cases. Laser therapy was recommended as part of complex treatment procedures for dust bronchitis patients.

[The relationship between the number of antibody forming cells in the spleens of rats immunized with Sal. typhi O-antigen and the number of background cells producing antibodies to that antigen]. / Zavisimost' chisla antiteloobrazuiushchikh kletok v selezenke krys, immunizirovannykh O-antigenom Sal. typhi, ot chisla fonovykk kletok, produtsiruiushchikh antitela k étomi antigenu

It was shown on 5 series of rats by the method of local passive hemolysis in gel that the number of antibody-forming cells (AFC) in the spleen after the immunization with O-antigen from Sal. typhi correlated with the number of background AFC to the given antigen in the animals of the same series. This, possibly, pointed to the fact that the number of spontaneous AFC reflected the number of B-lymphocyte immunocompetent to the given antigen and could be used - to some extent - for the assessment of the immunological reactivity to this antigen before the immunization.

[Influence of acute and chronic poisoning with dichloroethylene on the kinetics of antibody-forming cells and the plasmocytic reaction in the spleen of rats in immunization with the O-antigen of Sal. typhi]. / Vliianie ostrogo i khronicheskogo otravleniia dikhloretilenom na kinetiku antiteloobrazuiushchikh kletok i plazmotsitarnuiu reaktsiiu selezenki krys pri immunizatsii O-antigenom Sal. typhi

Local hemolysis in gel demonstrated in tests on rats that with its acute action in a concentration of 25 mg/l (1/2 CL50) dichlorethylene stimulates, while with subacute action in a concentration of 5 mg/l--inhibits the formation of cells producing antibodies to the typhoid antigen, as well as the plasmocytic reaction of the spleen following immunization of the O-antigen from Sal. typhi and also without it. In poisoning subject to a dynamic changed is also the number of the antibody forming cells (ABFC) after immunization, viz. their doubling time decreased, with stimulation the antibody formation becames less intensive, whereas with chronic action of the poison the doubling time increases and the dropoff in the number of ABFC gains in speed. It may be presumed that the effect of the poison under study on the immunogenesis is conditioned by the action of the poison on the number of immunologically competent cells-precursors, released for differentiation irrespective of the antigen's action, simultaneously and immediately upon its introduction, as well as on the extent of recruitment, multiple, non-changed passage from the precursors compartment into that of the ABFC, occurring at the level of the integral organism, possibly through the intermidiary of the endocrine and vegetative nervous systems.

Cyclic kinetics and mathematical expression of the primary immune response. Cyclic kinetics of antibody-forming cells following immunization with Salmonella typhi O-antigen.

The kinetics of antibody-forming cells (AFC) in the spleen of rats immunized with Salmonella typhi O-antigen was investigated. The number of nucleated cells of spleen and blood serum antibody titres in passive haemagglutination were determined in parallel. Cyclic changes in the number of antibody-forming cells were detected as three peaks on the 4th, 9th, and 13th days following immunization. The fluctuations of their number were not related to the total number of nucleated cells of spleen. The antibody titres reached their peak on the 10th day following immunization, decreased by the 14th day and rose again on the 16th day after immunization. Repeated increases of the number of AFC were probably due to the regular, not accidental, recruitment of committed precursors cells (memory cells).