Psychometric properties of the state Probability and Consequences Questionnaire for social anxiety disorder.

Cognitive models of social anxiety propose that overestimation of the probability and cost of negative evaluation plays a central role in maintaining the disorder. However, there are currently no self-report state-based measures of probability and cost appraisals. The current paper examines the psychometric properties of the Probability and Consequences Questionnaire for social anxiety (PCQ-SA), which measures probability and consequence appraisals both in anticipation of, and in response to, an impromptu speech task. A total of 532 participants were recruited for the present study, consisting of 409 participants with a principal diagnosis of Social Anxiety Disorder (SAD), and 123 non-clinical controls. Results of exploratory and confirmatory factor analyses supported a two-factor solution for the PCQ-SA. The PCQ-SA demonstrated excellent internal consistency, excellent test-retest reliability, good convergent validity at both time points (i.e., pre and post speech task), and sensitivity to treatment. Finally, using Receiver Operating Characteristic Curve Analysis, clinical cut-off scores were calculated for probability and consequences at both time points, with the PCQ-SA scales showing good sensitivity, specificity, and positive and negative predictive values. Overall, the results provide evidence that the PCQ-SA possesses excellent psychometric properties. The PCQ-SA is suitable for use in clinical and research settings to assess key cognitive maintaining factors for SAD.

Is good memory always a good thing? An early offset of infantile amnesia predicts anxiety-like behavior throughout development in rats.

Infants tend to forget experiences much more rapidly than older individuals, a phenomenon referred to as infantile amnesia. This robust, cross-species phenomenon is commonly used to examine memory development. However, in this set of experiments, we examined the novel hypothesis that the expression of infantile amnesia is related to resilience/vulnerability. We conditioned infant rats to associate a white noise with shock. Animals were tested for memory of the association ~1 week later. We found that infants that expressed better memory of the aversive association emitted more vocalizations (indicative of higher levels of distress) when separated from their mother earlier in infancy (Experiment 1). Better expression of memory in infancy also predicted higher levels of conditioned fear (Experiment 2) and anxiety-like behavior (in a light-dark box; Experiment 3) in adulthood. Furthermore, probiotic-treatment administered early in development reduced anxiety-like behavior in animals that exhibited good expression of memory for an aversive association learnt in infancy (Experiment 4). However, the same treatment was ineffective if administered in adulthood. Taken together, these results suggest that individual differences in infants' memory for an aversive association predict anxiety-like behavior throughout development, and that early administration of probiotics can reduce anxiety-like behavior in "at-risk" animals.