Subject(s)
Drug Carriers/chemistry , Drug Compounding/methods , Excipients/chemistry , Flurbiprofen/chemistry , Polyvinyls/chemistry , Coated Materials, Biocompatible/chemistry , Diffusion , Drug Evaluation, Preclinical , Flurbiprofen/administration & dosage , Materials Testing , Tablets, Enteric-CoatedABSTRACT
The aim of this study is to develop a once-daily sustained release matrix tablet of ibuprofen using hydroxypropyl methylcellulose (HPMC) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required sustained release profile tablets were directly compressed using Avicel pH 101 and Magnesium stearate. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model was based on linearity (coefficient of correlation). The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemistry , Ibuprofen/chemistry , Methylcellulose/analogs & derivatives , Chemistry, Pharmaceutical , Delayed-Action Preparations , Diffusion , Hypromellose Derivatives , Kinetics , Methylcellulose/chemistry , Models, Chemical , Solubility , Tablets , Technology, Pharmaceutical/methodsABSTRACT
Tablets are the most common dosage form. Tablets can be prepared by dry method and wet methods, both methods have their own significance as well as disadvantages. Dry method and particularly direct compression is most simplest method of tablet manufacturing. On the other hand granulation is a multiple processing method which add complexity and make validation and control difficult. For comparative study of atenolol tablets a new formulation was designed and compressed by direct compression method. Then it's physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test were performed and finally assay carried out for evaluation and characterization of this new formulation against other formulation available in the market.
