[Lipid metabolism and blood coagulation system function in patients with the late sequelae of closed craniocerebral trauma]. / Sostoianie lipidnogo obmena i svertyvaiushchei sistemy krovi u bol'nykh s otdalennymi posledstviiami zakrytykh cherepno-mozgovykh travm.

Long-term follow-up of the subjects who have suffered closed brain injury showed that in comparison to matched controls the injured young subjects demonstrated abnormalities in lipid metabolism and coagulation tending to atherosclerosis. The limits of the values by which the patients significantly differed from the controls as well as 7 specific for the patients signs of lipid metabolism and coagulation impairment have been determined. From 1 to 5 specific indications registered in 67 +/- 5% patients allowed the diagnosis in them of the injury sequelae. The mechanisms of the above atherosclerotic shifts may work through neuroregulatory derangements common for brain injury and atherosclerotic encephalopathy and enhancement of atherosclerosis course by the craniocerebral damage.

[The place and significance of the autonomic dystonia syndrome in the clinico-pathophysiological structure of the late sequelae of mild closed craniocerebral trauma]. / Mesto i znachenie sindroma vegetativnoi distonii v kliniko-patofiziologicheskoi strukture otdalennykh posledstvii legkikh zakrytykh cherepno-mozgovykh travm.

Analysis of the incidence, clinico-pathophysiological structure and dynamics of vegetovascular disorders in subjects with a history of mild closed craniocerebral injuries has demonstrated that in the majority of them, even practically healthy, functional insufficiency of vegetovascular functions is seen for many years after injury. Clinically, it manifests under the influence of diverse harmful exo- and endogenous factors, undergoes circadian changes, is altered during magnetic storms, in the course of traumatic disease and nonmedicamentous correction (by methods of adaptive bioregulation according to heart rhythm parameters, craniocerebral hypothermia, etc). It has been shown that initially transitory, reversible vegetovascular disturbances, provided they were not initially removed, transform with years to more stable vegetotrophic disorders and become risk factor of cerebrovascular diseases in the given group.

[The clinico-pathophysiological characteristics and functional diagnostic significance of disorders in general sensitivity in patients with an acute myocardial infarct]. / Kliniko-patofiziologicheskaia kharakteristika i funktsional'no-diagnosticheskoe znachenie narushenii obshchei chuvstvitel'nosti u bol'nykh ostrym infarktom miokarda.

Based on the results of a comprehensive investigation of superficial, deep and complex types of sensitivity, certain vegetative functions and the kallikrein-kinin system in patients with acute myocardial infarction (MI) at different stages of the disease, it has been shown that Zakhar'in-Head areas for the heart reflect the status of the sensor system only partially in the pathology under consideration. Correlations were established between disturbances in sensitivity and the course of MI, its clinical versions, complications and blood serum kinin content. According to the authors, the paper is concerned with sensor manifestations of the new (cardial) type of the reactive vegetative syndrome.

[Late sequelae of mild closed cranio-cerebral injuries (incidence, clinical course and criteria of the conditions of compensation and decompensation)]. / Otdalennye posledstviia legkikh zakrytykh cherepno-mozgovykh travm (chastota, techenie, kriterii sostoianii kompensatsii i dekompensatsii).

The authors present the results of clinical catamnestic, clinical neurologic analysis, and of specific neurophysiologic examinations of 292 patients with a history of slight craniocerebral injuries. Late sequelae of these injuries were detected in 70% of the examinees. The criteria and factors of decompensation risk were defined on the basis of the total and clinical structure of the disease, history of the injury, variation pulsometry, bioelectric reactivity, and visual analyzer adaptation function. The data may be used in prophylactic work to predict the course of these sequelae and for secondary prevention.

[Clinico-genealogical and phenotypic characteristics of patients with late sequelae of closed cranio-cerebral injuries]. / Kliniko-genealogicheskaia i fenotipicheskaia kharakteristika bol'nykh s otdalennymi posledstviiami zakrytykh cherepno-mozgovykh travm.

As many as 100 patients with late sequelae of closed craniocerebral injuries (CCCI) and 50 healthy persons underwent a clinico-genealogical and phenotypic analysis. Multifactorial diseases (in particular essential hypertension and other cardiovascular diseases) which correlate with the clinical features of late sequelae of CCCI were noted to occur in the patients' pedigree significantly more often as compared to normal persons. The patients manifest a high frequency of the stigmas of dysembryogenesis. After CCCI part of them manifested certain hereditary diseases. Genetic risk factors should be taken into account in forecasting CCCI outcomes and planning follow up measures.

[Sensory-pain adaptation in clinical neurology]. / K issledovaniiu sensorno-bolevoi adaptatsii v klinicheskoi nevrologii.

The article presents quantitative (temporal) and qualitative (phenomenological) characteristics of sensory-painful adaptation in clinically healthy subjects of various age and in patients with neuroses and organic lesions of different levels and of variable genesis. It has been ascertained that investigation of sensory-painful adaptation may be of a certain diagnostic significance.

[Status of different types of sensitivity in preschool children]. / Sostoianie razlichnykh vidov chuvstvitel'nosti u detei doshkol'nogo vozrasta.

Using special methods the authors examined the general sensitivity in clinically healthy pre-school children (5-7 years) in comparison with the results of examination of clinically normal adults (18-20 years) and patients with different levels and nature of foetal damage to the brain. The findings obtained in children include a shift of some types of general sensitivity in children toward their sharpening as well as signs classified in adults as manifestations of neural pathology. The identified characteristics of general sensitivity reflect some immaturity of afferent systems at early stages of their formation in children.

[Clinico-laboratory examination of patients with incipient cerebral atherosclerosis, neurasthenia and apparently healthy subjects of different age groups (comparative data)]. / Kliniko-laboratornoe obsledovanie bol'nykh nachal'nym tserebral'nym aterosklerozom, nevrasteniei i prakticheski zdorovykh lits raznykh vozrastnykh grupp (sravnitel'nye dannye).

Using unified research methods the authors studied 25 clinically healthy subjects aged 20-25 years and 35 subjects aged 35-50 years as well as 25 patients with neurasthenia aged 20-25 years and 35 patients aged 35-50 years with initial cerebral atherosclerosis (ICA). On the basis of correlations carried out by statistical methods, the most informative manifestations of ICA (clinically evident or latent), general and differential diagnostic criteria of neurasthenia and ICA and also "risk factors" were specified.

[Clinico-pathophysiologic characteristics of general sensation in patients with neurasthenia and hysterical neuroses]. / Kliniko-patofiziologicheskaia kharakteristika narushenii obshchei chuvstvitel'nosti u bol'nykh nevrasteniei i istericheskim nevrozom.

The authors have found that disturbances of general sensitivity are characteristic of not only patients with hysterical neurosis, but also of patients with neurasthenia. The clinical structure and the time course of those disturbances in both groups of the patients were found to be rather close. In general, they differ substantially from the sensitivity disturbances in neuroses described earlier. The leading mechanism of the development of those sensitivity disturbances consists in an impairment of the function of the limbico-reticular complex structures.

[General sensitivity disorders in temporal lobe lesions (clinical picture, pathogenesis, epilepsy syndrome significance)]. / Narusheniia obshchei chuvstvitel'nosti pri porazheniiakh visochnoi doli (klinika, patogenez, znachenie sindroma épilepsii).

A detailed study of various kinds of general sensitivity was carried out in 70 epileptic patients with the temporal localization of the foci. In most patients examined, sensor disturbances were noted, among which latent and indistinct variants prevailed. The following disturbances of the sensitivity were specified: a) homolateral; b) contralateral; c) combined (alternating); d) of temporal genesis proper (hypo- and hyperalgesias, viscerosensor phenomena, disturbances of adaptation to pain: disturbances of the discriminative forms of sensitivity of the types of deterioration of memory, attention, collation, differentiation, "epicritic hyperesthesia", etc.); e) secondary lemniscus-involving, associated with disturbances of the afferent system functions at the trunco-diencephalic and cortical levels; f) secondary extra-lemniscus (trunco-reticular); g) sensitivity disturbances correlating with the attacks of temporal epilepsy.

[An attempt to prognosticate the rehabilitation of patients who have sustained closed brain injury]. / Popytka prognozirovaniia reabilitatsii bol'nykh, perenesshikh zakrytye travmy golovnogo mozga

The authors studied at the early and remote stages of the disease the adaptational function of analyzers (visual, acoustic, olfactory) and constructive practical actions in 82 patients who had suffered from closed brain traumas in peace-time. The same studies were conducted in 59 patients with remote sequealae of brain injuries during the wartime (barotraumas) for comparison. The authors compared the results of the studies on patients with different outcomes of rehabilitation and different kinds of brain injury and depicted some indices and manifestations unfavourable or relatively favourable for a social and occupational prognosis.