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The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis.
Sredni-Kenigsbuch, Dvora; Shohat, Michael; Shohat, Batia; Ben-Amitai, Dan; Chan, Chi-Chao; David, Michael.
J Dermatol Sci ; 50(3): 232-5, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18242062

ABSTRACT

The immunomodulator, AS101, inhibits production of IL-10, IL-4 and expression of p38 MAPK, while increasing production of IFNgamma and IL-2. Together with its excellent clinical safety profile in humans, suggests a potential therapeutic use for AD.


Subject(s)
Adjuvants, Immunologic/pharmacology , Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/immunology , Ethylenes/pharmacology , Interleukin-10/metabolism , p38 Mitogen-Activated Protein Kinases/metabolism , Child , Humans , In Vitro Techniques
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