ABSTRACT
X-ray repair cross-complementing group 1 (XRCC1) is a scaffold protein and a key element in DNA base excision repair process. Although, the role of XRCC1 polymorphisms in male infertility has been studied broadly, it is still a matter of debate. Hence, in order to shed light on the problem, we performed a meta-analysis to evaluate the overall effect of XRCC1 polymorphisms in male infertility risk. Databases, Web of Science, PubMed, Scopus, and Google Scholar were searched until September 15, 2018. Afterwards, the genotypes' distribution, genotyping methods, and ethnicity groups were extracted, and overall analyses were conducted. A total number of five researches on 1,407 subjects and 974 controls were found to meet our criteria in this meta-analysis. The XRCC1 Arg399Gln (rs25487) polymorphism was analyzed. This is the first meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations (Tab. 2, Fig. 3, Ref. 26). Keywords: meta-analysis; male infertility; polymorphism; XRCC1 Arg399Gln.
Subject(s)
Genetic Predisposition to Disease , Infertility, Male , Polymorphism, Single Nucleotide , X-ray Repair Cross Complementing Protein 1 , Case-Control Studies , DNA-Binding Proteins , Humans , Infertility, Male/genetics , Male , Risk Factors , X-ray Repair Cross Complementing Protein 1/geneticsABSTRACT
AIM: The aim of this paper was to describe the prevalence of overweight (preobesity and obesity) among 7- to 13-year-old children in different parts of Jahrom City, Southern Iran, during 2008-2009. METHODS: A total of 1158 students (587 males and 571 females) aged 7-13 years were assessed over a period of 12 months. Schools were randomly selected in each district of the city, and the participating children were selected using stratified randomization for age, with the aid of a table of random numbers. Body Mass Index (BMI) was measured for each subject. We adopted the 5th, 85th and 95th percentiles of the CDC as cut-off points for thin, overweight and obese children, respectively, as generally accepted. RESULTS: Age of the children ranged from 7 to 13 years with a mean of 9.9 ± 1.6 years. A total of 58 boys (9.9%) and 57 girls (10%) were overweight, and the difference between them was not statistically significant. However, obesity was less prevalent among girls (4.9%) compared to boys (5.1%). CONCLUSION: In this survey, prevalence of obesity among girls and boys was 4.9% and 5.1%, respectively. The scope of prevalence of obesity is remarkable enough for a mid-size semi-industrialized society in comparison with heavy industrialized parts of Iran, thus there is an urgent need to target younger ages for prevention and implementation of public educational programs to curtail this rising trend of obesity in young men and women.
