ABSTRACT
The effect of irradiation with low power He-Ne laser on wound healing was studied. 42 wister rats were subjected to this experiment.<br>A open wound, 20mm in diameter as deep as muscle layer were made on the back of anesthetized animals.<br>To find the suitable energy density of laser irradiation, the wound was irradiated with He-Ne laser by energy density of 4J/cm<sup>2</sup> or 10J/cm<sup>2</sup> every other day until the wound completely healed. The wound healing was much more accelerated by irradiation with energy density of 4J/cm<sup>2</sup> than that of 10J/cm<sup>2</sup> and none-irradiated contorol group.<br>To find the suitable interval of laser irradiation, the wound was irradiated every other days, every 4 days or every other days in early stage until the wound completely healed. From this study, the wound healing was much more acceralated by irradiation at every other days than the others.<br>This result suggested that laser irradiation with energy density 4J/cm<sup>2</sup> at every other days is most effective for wound healing.