Herbicide/pesticide effects on intestinal epithelial growth.

The purpose of the present study was to examine the effects of some common herbicides and pesticides on the growth of normal intestinal and colonic epithelial cells. Preconfluent cultures of normal rat intestinal cells (IEC-6 cell line) and normal human colonic epithelial cells were treated with 0.05-50 microM doses of atrazine, diazinon, and endosulfan. After 3 days of treatment, the change in cell proliferation was quantified by cell counting or the MTT growth assay. Both intestinal and colonic epithelial cell cultures had increases in cell growth when treated with as little as 1.0 microM atrazine, diazinon, or endosulfan. The observed changes in both cultured intestinal and colonic cell growth rates were not due to the influence of the vehicle control dimethyl sulfoxide (DMSO). That is, the treatment of the cell cultures with concentrations of DMSO as high as 0.5% for 3 days resulted in no change in cell growth compared with untreated control cultures. A consistent observation with all three of the compounds was that the highest doses (50 microM) had the least "proliferative potential" in stimulating either IEC-6 cell or human colonic epithelial cell growth. Within the concentration range used, none of the herbicides or pesticides caused a decrease in cell proliferation below that of the untreated control cultures. Overall, treatment of IEC-6 cell cultures with atrazine, diazinon, or endosulfan produced a biphasic growth response, whereas the same treatment in the human colonic epithelial cell cultures produced a more sustained level of growth over the same period. This culture system may provide the basis for an in vitro model to further study the cellular and molecular basis of the effects of herbicides and pesticides on intestinal epithelial proliferation.

Menstrual cycles in nurses handling antineoplastic drugs.

Given the association between high-dose antineoplastic drug therapy and effects on gonadal function, a cross-sectional study was designed to explore the relationship between low-dose occupational exposure to antineoplastic questionnaire survey of the members of two national organizations for nurses was conducted, resulting in a sample of 1,458 female subjects. Subjects obtained from the two organizations were compared on major demographic and work characteristics and were found to be similar on most factors other than occupational exposure to antineoplastic drugs. An association was found between menstrual dysfunction and current handling of cancer drugs in subjects between ages 30 and 45 years [prevalence odds ratio (OR) = 1.6, confidence interval (CI) = 1.3-1.9]. A logistic regression analysis demonstrated that subjects ages 30-45 who were currently administering antineoplastic drugs had the highest adjusted OR (3.4, CI = 1.6-7.3) when compared with subjects with no previous or current handling. Additional risk factors significantly associated with menstrual irregularity were stress level of work and the interaction of smoking and stress.

Nature and prevalence of ribavirin aerosol administration in U.S. pediatric hospitals.

A survey was undertaken to determine the nature and prevalence of ribavirin aerosol administration in pediatric hospitals. Ribavirin was administered in 79.4% of the respondents' hospitals. The majority used head hoods for aerosol administration. Ventilators were the primary method used by 6% of the respondents. This study demonstrates typical types of ribavirin exposure and the need to evaluate effects of chronic exposure.

Occupational exposure to bloodborne diseases and universal precautions: measurement of health care workers' self reported attitudes.

1. As the numbers of persons infected with bloodborne diseases continues to increase, it is paramount that all health care workers exhibit behaviors reflecting unerring compliance with universal precautions. 2. Physicians and RNs who are highly trained in bloodborne diseases and universal precautions, who have the tools available for universal precautions, and who are exposed to people with bloodborne diseases, are overwhelmingly not complying with universal precautions. 3. To better understand how attitudes impact behaviors, a valid and reliable tool was developed which measured health care workers' attitudes toward bloodborne diseases and universal precautions. 4. Training programs addressing attitudes and knowledge may help change health care workers' non-compliant behaviors into behaviors reflecting compliance with universal precautions.

Establishing a nurse-managed health center: getting started.

Many nurses are deciding that the best way to meet health care needs of clients and ensure high quality care is to establish a nurse-managed health center. This article provides practical information on assessing the need for such a center, determining the scope of services to be provided, obtaining the financial resources needed, and determining the staff and facilities required. The application of this information can make the center a reality.

Corporate perspective of the role of the occupational health nurse.

One hundred and twenty-three Ohio employers were surveyed about expectations for occupational health nurse performance of 20 current and desired future activities. Employers identified activities that (a) the nurse was currently performing, or (b) would be desired in the future, or (c) were not appropriate for the nurse. Findings showed occupational health nurses are counseling employees, treating illness and injury, evaluating safe return to work, and tracking workers' compensation cases. Activities most desired in the future are analyses of trends in health programs and study of cost-effective health program alternatives. Activities most frequently selected require skills of evaluation, budgeting, and cost-benefit analysis. Most occupational health nurses have not had the opportunity to learn skills of fiscal management; therefore meeting employer expectations will require new education.

Decision making in case management of home healthcare clients.

Public health nurses face ethical decision-making dilemmas in their everyday practice, but how well are they prepared to make these decisions? This research study examined the decision-making capabilities of nurses in case management in regard to terminating and maintaining services in difficult client situations. The results showed that nurses varied in their decision-making capabilities and that their beliefs about case management were not always carried out in actual practice.

A family practice model of health care for homeless people: collaboration with family nurse practitioners.

The growth of a large population of people without permanent housing in the United States has brought with it the necessity to address the unmet health needs of this group. As homelessness spreads, its demographic pattern has become more heterogeneous, with young vulnerable families now the major subgroup. This paper explores issues of homelessness in Westchester County, N.Y., which, despite being the 10th richest county in the United States, has the highest per capita homeless rate in the state. Children younger than age 18 represent the majority of this group. Barriers to the delivery of health care services are described, including fragmented life-styles, lack of insurance, insensitivity of care givers, distance from services, and inflexibility of traditional sources of health care. A model that has been developed for delivery of services is discussed. This model, the Outreach Health Care Unit, is run by nurse practitioners in collaboration with family physicians and is centered at the site of social service activities for homeless families and single men in Yonkers, N.Y. It is a collaborative endeavor of a nursing school, community hospital family practice residency program, and a network of social service agencies. The use of this model for education and research is also discussed since the goal is to provide both health services and training for health care providers.

Cognitive skills & development competencies for conducting research critiques.

As the nursing profession expands its unique scientific body of knowledge, it is essential that all professional nurses become capable of evaluating the scientific and clinical merits of this information generated by nursing research. Three developmental levels of research critique skills are delineated by the nurse reader's competencies: novice, intermediate, and advanced. Each developmental level is described in relation to five cognitive skills which underlie the proposed competencies: knowledge, comprehension, analysis, evaluation, and synthesis.

Forging a nursing research agenda for New York State.

The Foundation of the New York State Nurses Association Inc., (hereafter Foundation), the Council on Nursing Research of the New York State Nurses Association (hereafter Council on Nursing Research), and the Delta Pi Chapter of the Sigma Theta Tau International (hereafter Delta Pi), sharing the same beliefs about nursing research and the need to take action, have worked cooperatively during the past three years to develop a nursing research agenda for New York state. Activities undertaken by these three groups to achieve this goal include co-sponsored conferences, a delphi survey to establish nursing research priorities for New York state, a research program offered at the 1989 Convention of the New York State Nurses Association, and establishment of the Foundation's Center for Nursing Research. A Planning Committee, with representatives from the three co-sponsoring organizations, has been appointed to assist the Center to further specify the action strategies for the research agenda and to oversee implementation of the agenda.

1988 Delphi survey of nursing research priorities for New York State.

In order to inform decisions about nursing research and health care policy, the Council on Nursing Research of the New York State Nurses Association (NYSNA) conducted a Delphi survey to identify the priorities for nursing research in New York state. The Delphi technique is a method of eliciting judgements from experts for the purpose of short-term forecasting and planning. The survey was conducted by mail in three rounds during 1988. Round I required participants to identify three primary research priorities for the nursing profession. In Round II participants ranked the 37 most frequently identified categories from Round I. The highest 16 categories from Round II were ranked by participants in Round III to provide the final 10 nursing research priority categories for New York state. All members of the New York State Nurses Association holding a minimum of a master's degree in nursing were invited to participate. The response rates were: Round I, 34% (N = 872); Round II, 38% (N = 985); Round III 37% (N = 974). Of the 10 nursing research priority categories identified in the final round, 5 relate to nurses, 2 relate to nursing, and 3 relate to clients. None of the high-risk conditions or populations with whom nurses work appear in the top 10, and only 2 of these are ranked in the top 15 priority categories. These priority categories will be used by the NYSNA Council on Nursing Research to influence its future agenda and activities. They can be used by the nursing profession and others for planning, policy making, and establishing nursing research funding priorities.(ABSTRACT TRUNCATED AT 250 WORDS)

Assessment of menstrual variability in working populations.

Though the relationship between exposure to chemicals and damage to ovarian tissue has been demonstrated, there have been few attempts to assess the effect of occupational exposures on menstrual cycles. Previous research has reported the mean cycle lengths and duration of flow for large populations. However, additional research is needed to analyze the variability of cycles of individual working women. Cycle length is the most assessable indicator of ovarian damage and subsequent effects on menstrual patterns, but the reliability of self-reports of cycle length has been shown to be poor. Improved methods to accurately assess individual menstrual variability are needed. Educational programs should be provided for workers to increase their knowledge of the effects of chemicals on reproductive functioning and ultimately to increase their sensitivity to recording accurate data on menstrual patterns. Numerous factors can affect the hypothalamic-pituitary-gonadal balance. The simultaneous effects of these factors and exposures to chemicals in the workplace need further investigation.