ABSTRACT
BACKGROUND: To compare quality of life (QoL) indices between ureteral stent (DJS) and nephrostomy tube (PCN) inserted in the setting of acute ureteral obstruction. METHODS: Prospective bi-centered study. Over the span of 2 years, 45 DJS and 30 PCN patients were recruited. Quality of life was assessed by 2 questionnaires, EuroQol EQ-5D and 'Tube symptoms' questionnaire, at 2 time points (at discharge after drainage and before definitive treatment). RESULTS: Patients' demographics and pre-drainage data were similar. There were no clinically significant differences in patient's recovery between the groups, including post procedural pain, defeverence, returning to baseline renal function, and septic shock complications. More DJS patients presented to the emergency room with complaints related to their procedure compared to PCN patients. At first, DJS patients complained more of urinary discomfort while PCN patients had worse symptoms relating to mobility and personal hygiene, with both groups achieving similar overall QoL score. At second time point, PCN patients' symptoms ameliorated while symptoms in the DJS group remained similar, translating to higher overall QoL score in the PCN group. CONCLUSIONS: The two techniques had a distinct and significantly different impact on quality of life. Over time, PCN patients' symptoms relieve and their QoL improve, while DJS patients' symptoms persist. Specific tube related symptoms, and their dynamics over time, should be a major determinant in choosing the appropriate drainage method, especially when definitive treatment is not imminent.
Subject(s)
Nephrostomy, Percutaneous , Quality of Life , Stents , Ureter/surgery , Ureteral Obstruction/surgery , Acute Disease , Adult , Aged , Female , Humans , Male , Middle Aged , Prospective Studies , Treatment OutcomeABSTRACT
The use of pseudoephedrine, an alpha agonist, for the treatment of retrograde ejaculation is well-known, however, there is no clear consensus from the literature regarding its efficacy and treatment protocol. We evaluated the efficacy of pseudoephedrine treatment in patients with retrograde ejaculation, utilizing a yet undescribed short-period treatment protocol. Twenty men were medically treated with pseudoephedrine for retrograde ejaculation between January 2010 and May 2016 (12 with complete retrograde ejaculation and 8 with partial retrograde ejaculation). All patients had a semen analysis and post-ejaculatory urinalysis before and after treatment. The treatment protocol consisted of 60 mg of pseudoephedrine every 6 h on the day before semen analysis and two more 60 mg doses on the day of the semen analysis. Diabetes was the most common etiology for complete retrograde ejaculation (60%), whereas an idiopathic cause was the most common etiology for partial retrograde ejaculation (82%). Of the 12 complete retrograde ejaculation patients treated with pseudoephedrine prior to semen analysis, 7 (58.3%) recovered spermatozoa in the antegrade ejaculate, with a mean total sperm count of 273.5 ± 172.5 million. Of the eight patients with partial retrograde ejaculation, five (62.5%) had a ≥50% increase in the antegrade total sperm count. In this group, the mean total sperm count increased from 26.9 ± 8.5 million before treatment to 84.2 ± 24.6 million after treatment, whereas the percentage of spermatozoa in the urine declined from 43.2 ± 9% to 17 ± 10%, respectively (both p < 0.05). Overall, in men with retrograde ejaculation treated with a pseudoephedrine regimen prior to ejaculation, some improvement in seminal parameters occurred in 14 (70%) patients, with 10 patients (38.5% of all patients) achieving antegrade total sperm counts over 39 million.
Subject(s)
Adrenergic alpha-Agonists/administration & dosage , Ejaculation/drug effects , Infertility, Male/drug therapy , Pseudoephedrine/administration & dosage , Sexual Dysfunction, Physiological/drug therapy , Adrenergic alpha-Agonists/adverse effects , Adult , Databases, Factual , Drug Administration Schedule , Humans , Infertility, Male/diagnosis , Infertility, Male/physiopathology , Male , Pseudoephedrine/adverse effects , Retrospective Studies , Sexual Dysfunction, Physiological/diagnosis , Sexual Dysfunction, Physiological/physiopathology , Sperm Count , Sperm Motility/drug effects , Time Factors , Treatment OutcomeABSTRACT
Our purpose was to find the utility of laboratory tests in emergency ward evaluation of patients with gastroenteritis. Medical records of 163 adult cases were retrospectively reviewed. Blood laboratory tests were drawn in 116 cases, 78 had at least one abnormality. Urine tested ketone-positive in 15 of 116 cases. One hundred fifteen were treated with intravenous fluids, 20 with antibiotics, and 4 were admitted. Fifty-eight stool cultures were sent, and 13 yielded enteric pathogens. Cultures from patients with fever or symptoms of long duration had higher yields (57% vs 11.3% and 38.1% vs 0%, P < 0.001, respectively), and when combined had sensitivity of 100% and specificity of 65%. There was no association between abnormal blood laboratory results, intravenous hydration, and antibiotic treatment with the stool culture being positive or with the patient being hospitalized. Laboratory tests are used often, but are very seldom contributory for evaluating domestically acquired gastroenteritis.
