ABSTRACT
A technique of the assessment of toxic effect of a combination of chemicals in soil on the organism of mammals has been developed. It is based on the investigation of the damaging effect of components of the combination when they get into the organism through the soil-contiguous media on the level of summary 24-hour doses, as well as when their residues get into the organism with food, water, air and through the skin. A method calculating the threshold dose of each component of the combination in soil according to the toxicological harm index is suggested.
Subject(s)
Environmental Exposure , Soil Pollutants/toxicity , Agriculture , Air Pollutants/toxicity , Animals , Drug Combinations , Female , Humans , Models, Theoretical , Pregnancy , Water Pollutants, Chemical/toxicityABSTRACT
From the total number of pesticides applied in the USSR, 18 are classified as being particularly dangerous compounds. Taking into account the self-purifying ability of the regional soils, arbitrary doses of these pesticides have been calculated for the administrative units of the Ukrainian SSR, the Moldavian SSR, and the water basin territories of the principal rivers in the region. This index is of greatest significance for arable and long-cultivated regions of the Crimea, Odessa, Kiev, Kherson, and Volynskiy, and for the Moldavian water basin territories of the Prut, the Dniester, and the Southern Bug.
