[Seasonal changes in cardiovascular indices and monoamine content in the brain of rabbits]. / Sezonnye izmeneniia serdechno-sosudistykh pokazatelei i soderzhaniia monoaminov v mozge krolika.

In our previous studies a rather substantial difference between the initial values of the cerebral blood flow was found. On the other hand the brain monoamine content varies in different months of the year when studied. Comparative analysis of these parameters in rabbit brain was the aim of this paper. The content of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in cortical and subcortical structures and the local cerebral blood flow (ICBF), the systemic arterial pressure (SAP) and pulse rate (PR) were studied. There were found seasonal variations in all parameters. A certain LCBF retardation in subcortical structures and cortex and the weakest effect of the stimulation was observed in May. There was a drop in SAP and some PR increase in the spring (April-May). Brain NA and 5-HT content showed seasonal changes with the lowest values near the winter months and reaching maximum in May as the PR does. Content of DA was low in May. So it seams possible that the ion ICBF in May can be explained by the decrease of brain DA at that time. The ICBF and the reactivity of cerebral microvessels seem to depend on the monoamine content and show seasonal variability.

[An approach to the experimental study of the intracerebral mechanisms regulating the cerebral blood circulation]. / O podkhode k éksperimental'nomu izucheniiu intratserebral'nykh mekhanizmov reguliatsii mozgovogo krovoobrashcheniia.

The principles of planning and conducting experiments in the field of cerebral circulation are discussed. The need in complex methods is emphasized. Own findings (cerebral blood flo EEG, pO2 of the cerebral tissue, systemic blood pressure, breathing, blood gases and pH) are discussed.

[Effect of electric stimulation or lesion of the thalamus on cerebral circulation]. / Vliianie élektrostimuliatsii ili razrusheniia zritel'nogo bugra na mozgovoe krovoobrashchenie.

Local cerebral blood flow (lCBF) in the thalamus and cerebral cortex was determined in 16 alert rabbits after electric stimulation of thalamic nuclei, and in 22 anesthetized dogs after thermocoagulation of posterior part of the thalamus. The cerebrovascular dilatory effect and increase in the lCBF were observed. Rheoelectroencephalographic investigations in 13 patients with parkinsonism subjected to stereotaxic lesion of thalamic ventrolateral nuclei also showed a diffuse reduction of arterial tone and cerebrovascular resistance. The data obtained seem to explain the reactive hyperemia which may develop primarily as a neurogenic reaction and then be maintained by metabolic changes.

[Role of diencephalic structures in the regulation of cerebral blood flow]. / Izuchenie roli diéntsefal'nykh struktur v reguliatsii mozgovogo krovotoka.

The effects of electric stimulation of the thalamus, hypothalamus and septum upon the CBF, pO2 of brain tissue, EEG, general arterial pressure and pneumogram, were studied in 74 rabbits with implanted cerebral electrodes. The stimulation mostly resulted in an increase in local blood flow sometimes accompanied by a decrease in cortical blood flow. Other parameters under study changed infrequently and insignificantly. The regulation of the CBF seems to be maintained by intracerebral mechanisms.

[The role of deep cerebral structures in the regulation of intracerebral microcirculation]. / Izuchenie roli glubinnykh mozgovykh struktur v reguliatsii intracerebral'noi mikrotsirkuliatsii.

Changes of the diameter of microvessels of the rabbit cortex, thalamus, hypothalamus, septum pellucidum, amygdala, hippocampus and globus pallidus were studied during electrical stimulation of these structures. The stimulation of amygdala elicited vasoconstrictive reactions, the stimulation of hypothalamus and septum--vasodilative reactions, the stimulation of thalamus, hippocampus and globus pallidus caused a vasoconstriction in the motor cortex and a vasodilatation in the subcortex. These results suggest participation of the deep brain structures in the regulation of brain microcirculation.

[Correlation between the anticonvulsant and tranquilizing effects of carbamazepine and methindione in experimental temporal epilepsy]. / Sootnoshenie mezhdu protivosudorozhnymi i trankviliziruiushchimi éffektami karbamazepina i metindiona pri éksperimental'noi visochnoi epilepsii

In 16 rabbits with chronic implanted electrodes the authors convened an electrostimulation of the hypocampus, the amygdale body and new cortex which brought to emotional-affective and EEG convulsive reactions. These reactions were inhibited by karbamazepine (150 mg/kg) and methindion (100 and 200 mg/kg) introduced into the gastrum. Karbamazepine possessed most inhibiting effect. The tranquillizing effect of methindion exceedes its anticonvulsive action, due to which it can be used both as an anticonvulsant and tranquilizing preparation. For this reason its combined effect should be most effective in temporal epilepsy.