ABSTRACT
A spectrophotometric method for the quantitative determination of dapsone (1) has been developed through a condensation reaction of 9-chloroacridine as a chromogen and the amino groups of 1. The reaction variables were investigated and optimized. The resultant colored products is stable and was synthesized. The application of the present method to the determination of 1 in commercial tablets gave satisfactory results and was compared with the official methods. The proposed method ist simple, sensitive, reproducible and accurate.
Subject(s)
Dapsone/analysis , Acridines , Hydrochloric Acid , Indicators and Reagents , Solvents , Spectrophotometry, Ultraviolet , Tablets , TemperatureABSTRACT
The quantitation of allopurinol, I, flucytosine, II, meclophenoxate hydrochloride, III, and phenylephrine hydrochloride, IV, in bulk drugs and tablets was achieved by simply developed, rapid and specific methods using the proton magnetic resonance (PMR) spectroscopy. Trifluoroacetic acid and dimethylmalonic acid were the solvent and the internal standard respectively.
