ABSTRACT
We studied the influence of nontoxic phytoadaptogen complex on the lifespan and somatic status (body weight, coat state, and motor activity) of CBA mice predisposed to spontaneous hepatomas. Administration of the complex phytoadaptogen during the first month of postnatal ontogeny increased mean animal lifespan by 17.1% (p<0.001) and median of survival by 25.6% (p<0.001) and promoted maintenance of satisfactory physical status of CBA mice during spontaneous hepatocarcinogenesis.
Subject(s)
Anticarcinogenic Agents/pharmacology , Antineoplastic Agents, Phytogenic/pharmacology , Carcinoma, Hepatocellular/drug therapy , Liver Neoplasms/drug therapy , Panax/chemistry , Rhodiola/chemistry , Animals , Anticarcinogenic Agents/isolation & purification , Antineoplastic Agents, Phytogenic/isolation & purification , Body Weight/drug effects , Carcinogenesis/drug effects , Carcinogenesis/pathology , Carcinoma, Hepatocellular/mortality , Carcinoma, Hepatocellular/pathology , Disease Susceptibility , Liver Neoplasms/mortality , Liver Neoplasms/pathology , Male , Mice , Mice, Inbred CBA , Plant Extracts/chemistry , Survival AnalysisABSTRACT
Using the model of breast cancer Ehrlich ascites tumor in mice, we showed that a sigle intraperitoneal injection of cardiac glycoside digoxin 1 h before the intraperitoneal injection of cisplatin increased the anticancer effect of the cytostatic drug more than twice when recalculated for the dose. It is assumed that the modifying effect of digoxin is determined by the direct inhibition of glycolysis in tumor cells. Taking into account the design of the study, we consider promising the clinical evaluation of the effectiveness of digoxin as a modifier of cisplatin efficiency in intracavitary therapy of ascites cancers with pleural and abdominal dissenmination.
