ABSTRACT
NMDA-mediated excitotoxicity considered as a main cause of neuronal death after stroke. Memantine is a non-competitive NMDA-receptor antagonist. This article reviews the recent results of experimental studies on the efficacy of memantine as an add-on to improve the safety of thrombolytic therapy.
Subject(s)
Brain Ischemia/drug therapy , Memantine/therapeutic use , Neurons/drug effects , Animals , Apoptosis/drug effects , Brain Ischemia/pathology , Excitatory Amino Acid Antagonists/therapeutic use , Humans , Neurons/pathology , Treatment OutcomeABSTRACT
The article describes current scientific views on the predictors of neurological complications caused by coronary artery bypass grafting (CABG) surgery. The authors present the results of the study clarifying the most important predictors of stroke and postoperative delirium. The predictive value of preoperative data of neuropsychological testing in the identification of risk factors for postoperative long-term cognitive decline in patients undergoing CABG has been shown.
