ABSTRACT
BACKGROUND: Previous animal and in vitro studies indicated that anthocyanidins might contribute to the prevention of obesity, while epidemiological evidences were scarce and had not been conducted in children. OBJECTIVE: We explored the associations between anthocyanidins and body composition in children. DESIGN: A cross-sectional study involving 452 children aged 6-9 years in Guangzhou, China, was carried out. Dietary information was collected using a 79-items food frequency questionnaire. Fat mass (FM), lean mass (LM), and fat mass percentage (FMP) at multi-sites (whole body, trunk, limbs, android area, and gynoid area) were measured using a dual-energy X-ray scan. Abdominal obesity was defined as an age- and sex-specific abdominal FM ≥ 85th percentile. Handgrip strength was measured using a hydraulic hand dynamometer. RESULTS: After adjusted for several potential covariates, higher dietary intake of anthocyanidin (per one standard deviation increase) was associated with a 0.013-0.223 kg increase of LM, a 0.024-0.134 kg decrease of FM, and a 0.63-0.76% decrease of FMP at multi-sites (P < 0.05). Results were similar and more pronounced for delphinidin and cyanidin, but less significant for peonidin. Higher dietary anthocyanidin intake (per standard deviation increase) was associated with a 41.0% (OR: 0.59, 95%CI: 0.37, 0.94) decreased risk of abdominal obesity. However, no significant associations were observed between anthocyanidin and handgrip strengths. CONCLUSIONS: Higher dietary intake of anthocyanidin and its components tended to be associated with better body composition, but not handgrip strength, in Chinese children at early age.
ABSTRACT
Studies of the relationship of copper (Cu), magnesium (Mg), and calcium (Ca) levels with blood pressure in children are limited. This cross-sectional study included 443 children aged 6-9 years from Guangzhou, China. Plasma concentrations of Cu, Mg, and Ca were measured by inductively coupled plasma mass spectrometry. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured with an electronic sphygmomanometer. Elevated SBP and DBP were defined as the 90th percentile or greater (age and sex specific) of reference values for Chinese children. Abnormal blood pressure (ABP) was defined as an elevated SBP and/or DBP. The plasma Cu concentration was positively correlated with blood pressure, body mass index (BMI), and the C-reactive protein (CRP) level, whereas the plasma Mg and Ca concentrations were negatively correlated with SBP. A higher Cu concentration (T3 vs. T1) was associated with a higher risk of ABP (odds ratio (OR) 2.55, 95% confidence interval (CI) 1.20 to 5.40). In contrast, children in the top tertiles of Mg (OR 0.42, 95% CI 0.18 to 0.98) and Ca (OR 0.28, 95% CI 0.11 to 0.70) concentrations showed lower risks of ABP than those in the bottom tertiles. Path analysis showed that the CRP levels and BMI mediated the associations between the Cu concentration and ABP. We found that higher plasma Mg and Ca concentrations were negatively related to blood pressure in children aged 6-9 years. In contrast, a higher plasma Cu concentration was positively correlated with the risk of ABP, and the association was mediated by CRP and BMI.
Subject(s)
Hypertension , Magnesium , Blood Pressure , Body Mass Index , Calcium , Child , China , Copper , Cross-Sectional Studies , Female , Humans , MaleABSTRACT
BACKGROUND: Former evidence regarding reference values of abdominal fat percentage (AFP) and optimal anthropometric indicators in predicting abdominal obesity measured by dual-energy X-ray absorptiometry (DXA) scan in Chinese children were scarce. METHODS: A total of 452 Chinese children aged 6-9 years were included in this cross-sectional study. Abdominal fat and lean mass were measured by a DXA scan, and AFP were calculated. Anthropometric indicators including body mass index (BMI), chest circumference (CC), waist circumference (WC) and hip circumference (HC) were measured, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) was also calculated. RESULTS: By defining abdominal obesity as those with an AFP ≥ 85th percentile, the cutoffs values are 24.80, 30.29, 31.58, 31.86% in boys, and 25.02, 30.32, 31.66, 31.79% in girls, for children aged 6, 7, 8, and 9 years old, respectively. All anthropometric indicators were independently and positively associated with AFP (P all < 0.01). In girls, BMI was found to be the optimal predictors of childhood abdominal obesity. The values of area under curves (AUCs) were significantly higher (P all < 0.05) than other anthropometric indicators, except for WHtR (AUCs value: 0.886). However, in boys, WHtR instead of BMI, provided the largest AUCs value (0.922) in predicting abdominal obesity, followed by BMI ((AUCs value: 0.913). CONCLUSION: This study provides reference values of AFP measured by DXA in Chinese children aged 6-9 years. BMI and WHtR tend to be the optimal anthropometric indicators in predicting abdominal obesity in Chinese girls and boys, respectively.
