ABSTRACT
BACKGROUND: People with posttraumatic stress disorder (PTSD) may have cognitive decline, a risk which can be particularly threatening at old age. However, it is yet unclear whether initial cognitive decline renders one more susceptible to subsequent PTSD following exposure to traumatic events, whether initial PTSD precedes cognitive decline or whether the effects are reciprocal. OBJECTIVE: This study examined the bidirectional longitudinal associations between cognitive function and PTSD symptoms and whether this association is mediated by depressive symptoms. METHOD: The study used data from two waves of the Israeli component of the Survey of Health, Ageing, and Retirement in Europe (SHARE), collected in 2013 and 2015. This study focused on adults aged 50 years and above (N = 567, mean age = 65.9 years). Each wave used three measures of cognition (recall, fluency, and numeracy) and PTSD symptoms following exposure to war-related events. Data were analyzed using mediation analysis with path analysis. RESULTS: Initial PTSD symptoms predicted cognitive decline in recall and fluency two years later, while baseline cognitive function did not impact subsequent PTSD symptoms. Partial mediation showed that older adults with more PTSD symptoms had higher depressive symptoms, which in turn were linked to subsequent cognitive decline across all three measures. CONCLUSIONS: This study reveals that PTSD symptoms are linked with subsequent cognitive decline, supporting approaches addressing this direction. It further indicates that part of this effect can be explained by increased depressive symptoms. Thus, treatment for depressive symptoms may help reduce cognitive decline due to PTSD.
ABSTRACT
Older cancer patients need to cope with two major stressful situations simultaneously - age-related stress and illness-related stress. The current study aimed to explore whether patients' quality of life (QoL) and functional limitations have a reciprocal effect over time, and further aimed to assess whether these effects differ by age group. Data were drawn from the two first waves of the Survey of Health, Ageing and Retirement in Europe. Five hundred ninety-eight participants reported that they were diagnosed with cancer or malignant tumours. All participants completed self-report questionnaires tapping personal and medical data, QoL and functional limitations. By using a two-wave cross-lagged design, findings showed a reciprocal relationship between QoL and functional limitations among older cancer patients. This reciprocal relationship was stronger in the direction from QoL to functional limitations, especially among those 75 and older in comparison with younger patients (50-74). This suggests that assessment of QoL may be beneficial to clinicians in predicting deterioration in functional limitations among older patients receiving cancer treatment.
