[The immunological diagnosis of peptostreptococcal infection]. / Immunologicheskaia diagnostika peptostreptokokkovoi infektsii.

The work deals with different methods for the diagnosis of anaerobic streptococcal infection, experimentally tested and clinically approved in the examination of children with acute pneumonia. The passive hemagglutination test, the immune rosette formation test and the specific lymphocyte blastogenesis test were used for diagnosis. As sensitin and antigen, the preparation of the peptostreptococcal bacterial mass was used. The diagnostic titer of antibodies to anaerobic streptococci was 1:160. A twofold and greater increase in the number of antigen-dependent rosette-forming lymphocytes and in specific blast transformation in the presence of the diagnostic antibody titer confirms the etiological role of anaerobic peptostreptococci in the development of pneumonia in children.

[Immunologic status of children living in a region with an increased level of nitrates in the drinking water]. / Immunnyi status detei, prozhivaiushchikh v raione s povyshennym soderzhaniem nitratov v pit'evoi vode.

Practically healthy schoolchildren living in the district with a high content of nitrates in drinking water experienced distinct quantitative and functional changes of immune indicators: violation of the ratio of immunoregulatory lymphocyte subpopulations, the high level of spontaneous T-lymphocyte blastogenesis, IgE-hyperglobulinemia. The above changes of the immune system could indicate both body sensitization and its desadaptation under unfavourable conditions.

[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. / Vliianie metronidazola na techenie éksperimental'noi anaérobnoi streptokokkovoi pnevmonii.

The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied. In the untreated animals the prolonged pathological process in the lungs is mainly associated with the suppression of the functional state of the thymus-dependent link of the immune system. Metronidazole suppresses anaerobic flora, stimulates local immune reaction and arrests the development of inflammatory changes in the lungs. The drug eliminates the unbalance in some subpopulations of immunocompetent cells and restores the number of cells regulating immune response to the normal level. The results obtained in this investigation make it possible to recommend the trial of metronidazole in the complex therapy of peptostreptococcal pneumonia.

[Mitosis pathology in experimental measles infection]. / Patologiia mitoza pri éksperimental'noi korevoi infektsii.

Experiments in monkeys, puppies, and guinea pigs showed both virulent and vaccine strains of measles virus to produce disorders in the reproductive apparatus of cells of the immunocompetent organs. The qualitative analysis of the pathological forms of mitosis abnormalities revealed mainly two types of the structural disorders of division: lethal forms and moderate forms not lethal for the cell. Virulent strains are characterized by predominance of lethal forms of pathology, vaccine strains by moderate lesions which are the source of mutations. In selection of prospective vaccine strains, their capacity to induce non-lethal forms of mitosis abnormalities should be taken into consideration.

[Associated action of the measles and mumps viruses on the lymphatic apparatus of guinea pigs]. / Izuchenie assotsiirovannogo deistviia korevogo i parotitnogo virusov na limfaticheskii apparat morskikh svinok.

The immunomorphological and cytopathological properties of vaccine strains of measles and epidemic mumps viruses inoculated individually and together were studied in experiments in guinea pigs. The optimal doses of measles and mumps monovaccines were found to produce morphological changes of similar intensity in the lymphatic apparatus of guinea pigs. Measles virus stimulated increased alterative changes in lymphoid elements with increased inoculations; mumps virus produced maximum degeneration of the cells immediately after the first inoculation. The combined injection of both viruses enhanced proliferation of lymphoid cells, the extent of their alteration and the frequency of pathological mitoses more than each monovaccine individually. The increased frequency of pathological mitoses occurred mainly due to moderate non-lethal changes in mitosis in which there was a likelihood of the appearance of viable cells with an altered karyotype.