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Eksp Klin Farmakol ; 58(1): 22-5, 1995.
Article in Russian | MEDLINE | ID: mdl-7787688

ABSTRACT

Murine experiments have demonstrated that excess sodium chloride intake has an aggravating effect on the course of convulsions caused by corazolum, thiosemicarbaside and maximum electric shock rather than strychnine. The new sodium chloride substitute hyposol given to animals ad libitum for a fortnight produces an anticonvulsant effect which is more pronounced in corazolum-induced convulsions and potentiates the anticonvulsant effect of diazepam. The official drug sanasol is antagonistic to strychnine and corazolum, but it displays a proconvulsant activity on a thiosemicarbaside model.


Subject(s)
Ammonium Chloride/therapeutic use , Anticonvulsants/therapeutic use , Calcium Gluconate/therapeutic use , Potassium Chloride/therapeutic use , Sodium Chloride, Dietary , Animals , Chi-Square Distribution , Convulsants , Drug Combinations , Drug Evaluation, Preclinical , Electroshock , Male , Mice , Mice, Inbred BALB C , Pentylenetetrazole , Seizures/chemically induced , Seizures/drug therapy , Semicarbazides , Sodium Chloride, Dietary/administration & dosage , Strychnine
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