[2-Methyl-3-phenylaminomethylquinolin-4-one as potential antidepressant with nootropic properties].

The new compound, 2-methyl-3-phenylaminomethylquinolin-4-on, belongs to V class of toxicity and exhibits antidepressant and antiamnesic properties. It is established that this compound reduces the duration of immobilization in the test of behavioral despair, prevents from the scopolamine induced amnesia, and exhibits antagonism with reserpine in mice. In a dose of 100 mg/kg, the synthesized compound influences the levels of cerebral catecholamines similarly to imipramine, but with a more pronounced decrease in the level of 5-hydroxytryptamine.

[Effect of medicinal plants on the excretory renal function (a review)].

The review summarizes verified data on the medicinal plants of world flora that influence the kidney excretory function. The biologically active substances of herbal preparations, the mechanisms of the renal effects, and the accompanying pharmacological properties of nephrotropic plants are considered.

[Increased use of sodium chloride modulates the diuretic effect of enalapril in intact rats and in rats with model edema syndrome].

Experiments on rats showed that the increased use of NaCl modulates the renal activity of enalapril. In animals with a model edema syndrome caused by subdiaphragm constriction of the interior vena cava, a hyper-NaCl diet enhances the Na-diuretic action of enalapril in both subacute and chronic stage of circulation insufficiency. In addition, enalapril increases the creatinin secretion in rats with this model (but not in intact animals). The administraton of enalapril in animals with caval obstruction receiving excess NaCl, in contrast to the case of standard diet, decreases the consumption of water, thus preventing the development of a positive balance of water.

[The effect of curiozin gel and adhesive plaster application on the healing and blood flow dynamics in skin autografts from various areas of body in rats]. / Vliianie kuriozin-gelia i applikatsiis leikoplastyria na prizhivlenie i krovotok v autotransplantantakh kozhi na raznykh uchastkakh tela u krys.

The stimulating effect of curiozin gel and plaster application on the engraftment of skin autografts from various areas of body was studied in rats. Curiozin gel in a single dose of 75 mg was used for the daily treatment of autografts over the entire postoperation period of time. The adhesive plaster was applied onto skin autografts for 5 days after skin transplantation. The skin autografts in the test group exhibited normalized volume blood flow dynamics, reduced duration of the inflammatory reaction, and improved the quality of engraftment as compared to the untreated control group. The best healing and blood-flow-normalizing effect was achieved by combined application of curiozin gel and adhesive plaster.

[Nephroprotective effect of bilobil in experimental acute kidney failure]. / Nefroprotektivnyi éffekt bilobila pri éksperimental'noi ostroi pochechnoi nedostatochnosti.

Bilobil, a commercial preparation based on Ginkgo biloba extract, improves the functional state of kidney and increases the survival of rats with glycerol-induced acute renal insufficiency. One possible mechanism of this effect is related to the ability of bilobil to simulate the renal antioxidant system, thus decreasing the rate of lipid peroxidation processes and reducing the renal damage. The results show good prospects for the use of bilobil in nephrology.

[Effect of furosemide on the intrarenal hemodynamics and excretory renal function depending on salt regime]. / Vliianie furosemida na vnutripochechnuiu gemodinamiku i vydelitel'nuiu funktsiiu pochek v zavisimosti ot solevogo rezhima.

The experiments on rats showed that the dietary mineral composition influences renal circulation and saluretic function and modifies the related effects of furosemide. In particular, a high NaCl intake reduces the blood perfusion in the renal cortex and increased that in the renal medulla, thus increasing sodium excretion with urine. The use of hyposol, a table salt substituent, enhances the blood flow in the renal medulla and leads to a significant increase in the diuresis, natriuresis, and kaliuresis. Furosemide (10 mg/kg) sharply increases the medullar circulation and electrolyte excretion on the background of standard diet. However, these effects were much less pronounced on the background of hypersodium diet or hyposol administration.

[The role of salt regime and modulation of hemorheologic effects of trental in rats with experimental circulatory insufficiency]. / Rol' solevogo regima i moduliatsiia gemoreologicheskikh éffektov trentala pri éksperimental'noi nedostatochnosti krovoobrashcheniia.

Experiments on rats showed that experimental circulatory insufficiency negatively affects the hemorrcological properties. A change in the mineral intake influences some of the hemorreological characteristics. The sodium chloride substitute hyposol (giposol) increased the osmotic resistance reduced the cholesterol level in the erythrocyte membranes On the gyposol background, trental normalized the volume blood flow. Thus, balanced mineral compositions may be a useful additional component in the complex therapy of circulatory insufficiency.

[Cerebrovascular and renal actions of bilobil and its effect on the metal ligand homeostasis (clinico-experimental study]. / Tserebrovaskuliarnye, renal'nye éffekty bilobila i ego vliianie na metalloligandnyi gomeostaz (kliniko-éksperimental'noe issledovanie).

The tests on rats with common carotid artery occlusion showed that bilobil increases the cerebral blood flow and decreases brain edema, thus decreasing the loss of experimental animals. The drug also increases the blood circulation and improves the excretory function of kidneys. Under clinical conditions, bilobil increases the cerebral blood flow, normalizes the metal ligand homeostasis, and improves the antioxidant status in children with early forms of cerebrovascular disease (neurocirculate distonia) and attention deficit hyperactivity syndrome.

[Cerebrovascular and renal effects of cerebrolysin and dependence on salt intake]. / Tserebrovaskuliarnye i renal'nye éffekty tserebrolizina v zavisimosti ot solevogo rezhima.

Experiments on rats with occluded common carotid arteries showed that an excess sodium chloride consumption increased the loss of test animals as a result of the maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute hyposol (giposol) reduced the extent of cerebral ischemia and brain swelling effect and increased the renal perfusion and diuresis levels. In the test animals receiving a high-Na diet, the efficacy of cerebrolysine was less pronounced. In contrast, hyposol increased the antiischemic, saluretic and antiswelling effects of cerebrolysine under the carotid artery occlusion.

[The mineral dietary composition affects glucose metabolism and modulates insulin effect in intact rats]. / Vliianie mineral'nogo sostava ratsiona na obmen gliukozy i moduliatsiia deistviia insulina u intaktnykh krys.

The experiments on intact rats showed that an excess sodium chloride consumption and the use of giposol (NaCl substitute) produce a hypoglycemic effect. Giposol increases, whereas NaCl decreases, the glucose tolerance. Giposol activates hexokinase and glucose-6-phosphate dehydrogenase (the key enzymes of the glucose metabolism in tissues) and reduces the effect of insulin. Both giposol and NaCl increase the level of glucose absorption in small intestine. The gastric motility is activated by NaCl and not affected by giposol.

[The modulation of the pharmacological effect of a number of substances by the mineral composition of the diet]. / Moduliatsiia farmakologicheskogo éffekta riada veshchestv mineral'nym sostavom ratsiona.

In acute and chronic experiments on rats (intact animals and animals with model circulatory insufficiency) which received 4 variants of the mineral additives over a period of 1-2 months the effect of mesatonum, isadrinum, and tiramine on the arterial pressure or furosemide and dichlorthiazide on the renal excretion function are studied. It is found that a substituent of the coom salt, hyposol, modulates in strength and in duration the hemodynamic effects of adrenergic drugs and renal excretion of electrolytes and water upon introduction of diuretics. On the whole, the effect of hyposol is aimed at attaining the favourable regime of functioning of the circulatory system.

[The action of adrenergic agonists and antagonists on kidney function and arterial pressure depending on the mineral component of the diet]. / Deistvie adrenergicheskikh agonistov i antagonistov na funktsiiu pochek i arterial'noe davlenie v zavisimosti ot mineral'nogo sostava ratsiona.

The experiments on rats showed that high consumption of sodium chloride promotes the diuretic action of phenylephrine (mesaton), the alpha-adrenergic agonist, and prolong its pressor effect. In supplementation of diet with sanasol and hyposol, a new substitute of common salt, phenylephrine, causes the renal effects typical of beta-adrenoceptor stimulation. Both the sanasol and especially hyposol decrease the strength and duration of phenylephrine pressor action and increase the duration of isadrine depressor effect. Thus, the reactivity of alpha- and beta-adrenergic mechanisms depend on the mineral composition of diet, which is able to change the pharmacodynamics of cardiovascular agents.

[A comparative study of the anticonvulsant action of a new table salt substitute]. / Sravnitel'noe issledovanie protivosudorozhnogo deistviia novogo zamenitelia povarennoi soli.

Murine experiments have demonstrated that excess sodium chloride intake has an aggravating effect on the course of convulsions caused by corazolum, thiosemicarbaside and maximum electric shock rather than strychnine. The new sodium chloride substitute hyposol given to animals ad libitum for a fortnight produces an anticonvulsant effect which is more pronounced in corazolum-induced convulsions and potentiates the anticonvulsant effect of diazepam. The official drug sanasol is antagonistic to strychnine and corazolum, but it displays a proconvulsant activity on a thiosemicarbaside model.

[The effect of the mineral composition of the diet on cholesterol metabolic indices and the experimental correction of propranolol-induced atherogenic dyslipoproteinemia]. / Vliianie mineral'nogo sostava ratsiona na pokazateli obmena kholesterina i éksperimental'naia korrektsiia aterogennoi dislipoproteidemii, vyzvannoi propranololom.

Rat experiments have revealed that surplus sodium chloride intake causes dyslipoproteinemia and intensifies the atherogenic action of propranolol. The new antihypertensive and antiedematous table salt substitute, as sanasole exerts its hypocholesterolemic effect. Both dietary salt mixtures eliminates the atherogenic action of beta-adrenoblocker. The application of table salt substitutes may become a convenient and effective agent against risk for atherogenesis.

[The effect of the table salt substitute sanasol on arterial pressure, water-salt metabolism and kidney functions in experimental pathology of circulatory homeostasis]. / Vliianie zamenitelia povarennoi soli sanasola na arterial'noe davlenie, vodno-solevoi obmen i funktsii pochek pri patologii tsirkuliatornogo gomeostaza v éksperimente.

The potassium-containing salt substitute sanasol was examined for its effects on blood pressure and renal function in normo- and hypertensive rats, as well as on the edematous syndrome in circulatory insufficiency. The antihypertensive and occasional antiedematous effects of sanasol resulted in unfavorable changes in electrolyte balance. Sanasol was found to be ineffective in experimental renal failure.

[The dose-dependent effect of mezaton and fetanol on the glucose level of the blood]. / Dozozavisimoe vliianie mezatona i fetanola na soderzhanie gliukozy v krovi.

Experiments with mice and rabbits have revealed that mezaton and fetanol in a dose of 0.1 mg/kg are able to cause heterodirectional changes in blood glucose levels. When their dose is increased to 1 and 10 mg/kg, the two agents result in hyperglycemia.

[The antiedematous activity of a table salt substitute, veroshpiron and furosemide in experimental circulatory failure]. / Protivootechnaia aktivnost' zamenitelia povarennoi soli, veroshpirona i furosemida pri éksperimental'noi nedostatochnosti krovoobrashcheniia.

On the model of circulatory insufficiency and secondary aldosteronism in rats it was shown that a new table salt substitute normalizes like spironolactone the extracellular fluid volume whereas furosemide exerts a less marked dehydrating action. The antiedema effect of the substitute of table salt is due to a decrease in drinking activity, an increase in natriuresis, normalization of aldosteronism.