An n-of-1 Trial Service in Clinical Practice: Testing the Effectiveness of Liuwei Dihuang Decoction for Kidney-Yin Deficiency Syndrome.

Objective. To describe the clinical use of n-of-1 RCTs for kidney-Yin deficiency syndrome that is a traditional Chinese medicine syndrome in publicly clinical practice in China. Methods. Our study included patients with kidney-Yin deficiency syndrome, using a within-patient, randomized, double-blind, crossover comparison of Liuwei Dihuang decoction versus placebo. Outcome Measures. Primary outcome measures included number of individual completion rates, response rate, and post-n-of-1 RCTs decisions. Secondary measures were the whole group score of individual Likert scale, SF-36 questionnaire. Results. Fifty patients were recruited and 3 were not completed. Forty-seven patients completed 3 pairs of periods, 3 (6.38%) were responders, 28 (59.57%) were nonresponders, and 16 (34.05%) were possible responders. Doctors and patients used the trial results to making decision. Three responders stayed on the medication management, 28 nonresponders ceased the LDD, 7 patients of the 16 possible responders could not give clear decision, and the others kept the same medication station. Among the whole group, neither the individual Likert score nor the SF-36 showed any statistical differences between LDD and placebo. Discussion. More attention should be paid to choose experienced TCM doctor as investigator and keep the simulant same with test medication in n-of-1 RCTs of TCM and sufficiently biological half-life period of Chinese medicine compound.

Clinical experience of professor HAN Bing in treating infertility / 中华中医药杂志

Professor HAN Bing is one of the second group of prestigious TCM experts in china .He is a famous TCM gynecologic expert,engaged in the medical services for 50 years.He has sufficient clinical experience,and is also good at using the theory of the eight extra meridians to diagnosis and treat the difficult and complicated gynecopathy.It is fortunate for the author as professor HAN Bing’s academic successor to study with teacher,and learn a lot from him.This article sorted part of the clinical effective cases and methods on treating infertility,which includes:method of kidney-invigorating and chong-vessel-regulating;liver-relieving and chong-vessel-regulating;method of diffusing and obstruction-removing dai meridian,and also enumerated four typical medical cases.