ABSTRACT
119 specimens of blood sera collected from measles cases with different vaccination history (aged 4 months to 48 years) on 5th-6th days after rash onset were Investigated using EIA. The obtained results showed that the primary immune response (PIR) was developed in 59 patients; the secondary immune response (SIR) was developed in 60 patients with a significant increase in the specific high avidity IgG (22.34 IU/ml +/- 3.2). The specific IgM were detected in 100% cases studied with capture ELISA in both previously vaccinated and unvaccinated individuals of different age. The specific IgM were detected by indirect ELISA in 100% cases in unvaccinated patients, while IgM positive sera was defined only in 23.3% of individuals with SIR. It was concluded that measles virus infection in previously vaccinated and unvaccinated adults had clinical differences. The role of patients with SIR in virus transmission was discussed.
Subject(s)
Immunoglobulin G , Immunoglobulin M , Measles Vaccine , Measles virus , Measles , Adolescent , Adult , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Humans , Immunoglobulin G/blood , Immunoglobulin G/immunology , Immunoglobulin M/blood , Immunoglobulin M/immunology , Infant , Measles/blood , Measles/immunology , Measles Vaccine/immunology , Measles virus/immunology , Measles virus/isolation & purification , Measles virus/pathogenicity , Middle Aged , VaccinationABSTRACT
In the clinical trials of vaccine TEOVac in lower and reglamented doses under the conditions of remote vaccination, carried out on 11 volunteers, local reactions in the form of hyperemia, gingival edema (1 vaccinee), faucial hyperemia, enlargement of submaxillary lymph nodes (2 vaccinees) were registered in some of the vaccines; in one vaccinee systemic postvaccinal reaction of medium gravity was observed. Revaccination produced no negative effect on the hematological and biochemical characteristics of the blood, as well as on the urine characteristics. The study of the sensitizing vaccine to the antigens of the accumulation substrate (chick embryo), as well as its influence on the development of autoimmune reactions, revealed the absence of the allergic action of the preparation and its influence on autoimmune processes in the vaccines. The trial of the smallpox vaccine in tablets under the conditions of the primary immunization of adults was the topical and most promising trend in the improvement of smallpox vaccination, as the preparation TEOVac proved to be safe, in contrast to the traditional smallpox vaccine introduced by the scarification method, for both vaccines and nonimmunized persons having contacts with them.
Subject(s)
Immunization, Secondary/adverse effects , Smallpox Vaccine/adverse effects , Smallpox/prevention & control , Vaccination/adverse effects , Administration, Oral , Adult , Edema/pathology , Female , Gingiva/pathology , Gingival Diseases/chemically induced , Gingival Diseases/pathology , Humans , Hyperemia/chemically induced , Lymph Nodes , Lymphadenitis/chemically induced , Male , Smallpox Vaccine/administration & dosage , Submandibular Gland , Tablets , Time Factors , Vaccines, Attenuated/administration & dosage , Vaccines, Attenuated/adverse effectsABSTRACT
One-dimensional localization of sodium atoms in a standing spherical light wave has been observed. The atoms have an oscillatory motion with an amplitude of approximately lambda/10 along the nodes (or loops) of the wave.
