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Chlorocardicin, a monocyclic beta-lactam from a Streptomyces sp. II. Isolation, physico-chemical properties and structure determination.

Chan, J A; Shultis, E A; Dingerdissen, J J; DeBrosse, C W; Roberts, G D; Snader, K M.

J Antibiot (Tokyo) ; 38(2): 139-44, 1985 Feb.

Article in English | MEDLINE | ID: mdl-3838979

ABSTRACT

Chlorocardicin, a novel monocyclic beta-lactam, was isolated from the fermentation broth of a Streptomyces sp. by the use of non-ionic porous resin and reverse phase chromatography. This chlorine-containing antibiotic is structurally related to nocardicin A. Its physico-chemical characteristics and detailed NMR analysis are described.

Subject(s)

Anti-Bacterial Agents/analysis , Lactams , Streptomyces/analysis , beta-Lactams , Anti-Bacterial Agents/classification , Anti-Bacterial Agents/isolation & purification , Chemical Phenomena , Chemistry , Chromatography/methods , Magnetic Resonance Spectroscopy , Spectrophotometry, Ultraviolet , Streptomyces/metabolism , Structure-Activity Relationship

Microbial resistances: a predictive test for streptothricin antibiotics.

Mehta, R J; Oh, Y K; Sitrin, R D; Shultis, E A; Nash, C H.

J Antibiot (Tokyo) ; 34(11): 1501-3, 1981 Nov.

Article in English | MEDLINE | ID: mdl-6274835

Subject(s)

Anti-Bacterial Agents/pharmacology , Drug Resistance, Microbial , Streptothricins/pharmacology , Chemical Phenomena , Chemistry , Microbial Sensitivity Tests

p-Dimethylaminobenzonitrile. A chemically simple coccidiostat.

Parish, R C; Theodorides, V J; Kunkle, D W; Dietz, E M; Shultis, E A.

J Med Chem ; 15(12): 1324-5, 1972 Dec.

Article in English | MEDLINE | ID: mdl-4635981

Subject(s)

Antiprotozoal Agents/chemical synthesis , Coccidiosis/drug therapy , Eimeria , Nitriles/chemical synthesis , Animals , Antiprotozoal Agents/therapeutic use , Benzoates/chemical synthesis , Benzoates/therapeutic use , Chickens , Dimethylamines/chemical synthesis , Dimethylamines/therapeutic use , Drug Synergism , Male , Nitriles/therapeutic use , Structure-Activity Relationship

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