[Screening audiological control in children of different ages after taking ototoxic medications]. / Skriningovyi audiologicheskii kontrol' detei raznogo vozrasta posle priema ototoksicheskikh preparatov.

AIM: To compare auditory function during screening of children of different age groups who received ototoxic therapy. PATIENTS AND METHODS: Auditory function was studied in various categories of children receiving ototoxic drugs. Hearing was assessed by the registration of distortion product otoacoustic emission (DPOAE), short-latency evoked potentials (SLEP), tympanometry. Statistical processing was performed using the C program Statgraphics Centurion XV. RESULTS: In this study, screening of auditory function in children suffering from cystic fibrosis and receiving ototoxic treatment revealed pathologic conditions of the middle ear according to tympanometry in 15.4% of cases, impaired auditory function in 28.2% of cases according to DPOAE. Early ototoxicosis presented as a decrease in the amplitude of the response at a frequency of 4 kHz, and a change in the structure of the DP-gram in the form of a shift to the low-frequency area. Examination of the auditory function of premature infants receiving potentially ototoxic drugs in the early neonatal period demonstrated that the administration of ototoxic drugs does not affect the maturation of outer hair cells. CONCLUSION: Audiological control, such as tympanometry and registration of evoked otoacoustic remission should be included in the outpatient observation of children with a history of ototoxic drugs.

[Difficulties of morphological diagnosis of inflammatory bowel disease based on the endoscopic biopsy in children].

Pathology diagnostics of inflammatory bowel diseases (IBD) in children on the material of colonobiopsies presents considerable difficulties. Definitive morphological diagnosis could be done probably no more than at half of the patients with suspicion on IBD. Diagnosis of unlassified colitis it is necessary to use to the diagnosis in more than 25% of cases. Whether at use of the given term it is desirable to specify in addition the impossibility to classify colitis between ulcerative colitis (UC) and Crohn's disease (CD) concerns or the differential diagnosis should include wider spectrum chronic colitidies. The similar situation always demands profound interdisciplinary discussion and the subsequent dynamic follow up the patient.