1.
J Med Chem
; 20(9): 1225-7, 1977 Sep.
Article
in English
| MEDLINE
| ID: mdl-926125
ABSTRACT
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.
Subject(s)
Anthelmintics/therapeutic use , Fascioliasis/drug therapy , Sulfonamides/therapeutic use , Animals , Anthelmintics/chemical synthesis , Anthelmintics/toxicity , Cattle , Fasciola hepatica , Sheep , Sulfanilamides , Sulfonamides/chemical synthesis , Sulfonamides/toxicity , Trichloroethylene/analogs & derivatives , Trichloroethylene/chemical synthesis , Trichloroethylene/therapeutic use
2.
Br Vet J
; 133(2): 211-4, 1977.
Article
in English
| MEDLINE
| ID: mdl-608060
Subject(s)
Antiplatyhelmintic Agents/therapeutic use , Cattle Diseases/drug therapy , Fascioliasis/veterinary , Sheep Diseases/drug therapy , Sulfanilamides/therapeutic use , Trichloroethylene/analogs & derivatives , Animals , Cattle , Fascioliasis/drug therapy , Female , Male , Sheep , Trichloroethylene/therapeutic use
3.
J Org Chem
; 31(5): 1638-9, 1966 May.
Article
in English
| MEDLINE
| ID: mdl-5931942
