ABSTRACT
Normally the rat gingival microcirculatory bed is represented by superficial capillaries, postcapillaries, arterioles, and venules of different diameters. The major changes characterizing microcirculation disorders in experimental periodontitis are edema, arteriolar constriction and dilatation, stasis, and thrombosis, which undergo variously directed shifts in different periods of pathological process.
Subject(s)
Gingiva/blood supply , Periodontitis/pathology , Animals , Microcirculation/physiology , Periodontitis/etiology , Rats , Reference ValuesABSTRACT
Grave inflammatory destructive lesions of the periodontium were induced in rats by ligature of canine pericervical area and cyclophosphamide injection. Histological analysis showed regression of inflammatory destructive changes on days 20 and 30 in the majority of animals injected indometaphene after the above experimental exposure but no regression in animals injected no indometaphene.