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Vopr Med Khim ; 29(4): 131-5, 1983.
Article in Russian | MEDLINE | ID: mdl-6623989

ABSTRACT

An improved, simplified and relatively rapid procedure is developed for isolation and purification of a new antitumor enzyme--methionine gamma-lyase from Pseudomonas putida. The method includes five steps instead of seven steps in previous procedure with a good yield of the enzyme. The purified enzyme was shown to be homogeneous by the criteria of disc gel electrophoresis. The highly homogeneous preparations of the enzyme exhibited the absorption maxima at 280 and 420 nm. The detailed studies on antileukemic activity of the methionine gamma-lyase are currently in progress.


Subject(s)
Carbon-Sulfur Lyases/isolation & purification , Lyases/isolation & purification , Pseudomonas/enzymology , Antineoplastic Agents , Carbon-Sulfur Lyases/metabolism , Carbon-Sulfur Lyases/therapeutic use , Humans , Leukemia/drug therapy , Spectrophotometry
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