ABSTRACT
The effect of the thymus polypeptide factor-thymidin on the lipid spectrum of the blood, thymic factor content in the blood and clinical course of the disease were studied in 156 patients with exertion stenocardia (II-IV functional class). Results indicate that patients with exertion stenocardia show with advance of the disease a reduction of the blood thymic factor and 85.6% develop hyperlipidemia. Complex treatment with inclusion of thymalin resulted in an increase of the thymic factor, normalization of the lipid metabolism increase of the contractile function of the myocardium and, thus, increases the treatment efficacy.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Lipids/blood , Myocardial Ischemia/drug therapy , Thymus Hormones/therapeutic use , Adult , Angina Pectoris/blood , Angina Pectoris/drug therapy , Combined Modality Therapy , Drug Evaluation , Female , Humans , Male , Middle Aged , Myocardial Ischemia/blood , Physical ExertionSubject(s)
Myocardial Infarction/complications , Pulmonary Edema/etiology , Aged , Female , Humans , Male , Middle Aged , Myocardial Infarction/physiopathologySubject(s)
Carboxypeptidases/blood , Kallikreins/blood , Kinins/blood , Lysine Carboxypeptidase/blood , Myocardial Infarction/blood , Pulmonary Edema/blood , Aged , Aprotinin/therapeutic use , Drug Therapy, Combination , Esterases/blood , Female , Humans , Male , Middle Aged , Myocardial Infarction/complications , Myocardial Infarction/drug therapy , Nitroglycerin/therapeutic use , Pulmonary Edema/drug therapy , Pulmonary Edema/etiology , alpha-Macroglobulins/metabolismSubject(s)
Polyps/diagnosis , Tracheal Neoplasms/diagnosis , Adult , Asthma/diagnosis , Diagnosis, Differential , Female , Humans , Male , Middle AgedSubject(s)
Capillary Permeability , Coronary Disease/physiopathology , Adult , Coronary Disease/drug therapy , Female , Heparin/therapeutic use , Humans , Male , Middle AgedSubject(s)
Amiodarone/therapeutic use , Angina Pectoris/drug therapy , Benzofurans/therapeutic use , Adult , Aged , Drug Evaluation , Female , Humans , Male , Middle AgedSubject(s)
Capillary Permeability , Coronary Disease/physiopathology , Acetylcholine/metabolism , Adrenal Glands/physiopathology , Arteriosclerosis/physiopathology , Catecholamines/metabolism , Coronary Disease/metabolism , Glycosaminoglycans/metabolism , Heparin/metabolism , Humans , Hyaluronoglucosaminidase/metabolism , Pyruvates/metabolism , Receptors, Adrenergic , Receptors, CholinergicSubject(s)
Heart Neoplasms/complications , Lung Neoplasms , Adult , Humans , Male , Neoplasm Metastasis , Rupture, SpontaneousSubject(s)
Immunoglobulins/isolation & purification , Pneumonia/immunology , Acute Disease , Adolescent , Adult , Aged , Chronic Disease , Female , Humans , Male , Middle AgedABSTRACT
In patients with coronary atherosclerosis in I and III stages content of histamine in blood, excretion of free histamine with urine, activities of serum histidine decarboxylase and diaminooxidase, histaminopexy of blood serum and content of antihistamine factor were studied. In patients with the disease of the I stage during the attacks of stenocardia content of histamine in blood, the activity of diaminooxidase and content of degranulated basophils were increased, but the histidine decarboxylase activity, histaminopexy, content of antihistamine factor and excretion of free histamine with urine were normal. During the stenocardia attacks in patients with coronary atherosclerosis of the III stage content of degranulated basophils, the histidine decarboxylase activity were increased, histaminopexy and titres of antihistamine factor were decreased. Between the content of histamine in blood and the diaminooxidase activity no correlation was observed. This lack of correlation could cause development of hyperhistaminaemia and increased excretion of free histamine with urine. Antihistamine and desensitizing preparations (pipolphen, heparin, amidopyrine and ascorbic acid) increased the therapeutic efficiency of vasodilating drugs, decreased stenocardia attacks, accelerated both clinical improvement and normalization of histamine metabolism.