ABSTRACT
With the introduction of potent immunosuppressive and chemotherapeutic medications for various diseases, there is an increased incidence of therapy-related myeloid neoplasms. They are the result of mutational rearrangement and historically, have a grave prognosis compared with de novo myeloid neoplasms. We did a short review on various types of myeloid leukaemias reported after therapy with antitumour necrosis factor and also report, to the best of our knowledge, one among the very few cases of therapy-related acute promyelocytic leukaemia in a patient on infliximab therapy for refractory Crohn's disease. The patient responded well to the traditional treatment and is in complete remission for more than 5â years.
Subject(s)
Antibodies, Monoclonal/adverse effects , Crohn Disease/drug therapy , Leukemia, Promyelocytic, Acute/chemically induced , Leukemia, Promyelocytic, Acute/pathology , Adult , Antibodies, Monoclonal/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Needle , Bone Marrow Examination , Crohn Disease/diagnosis , Female , Follow-Up Studies , Humans , Immunohistochemistry , Infliximab , Leukemia, Promyelocytic, Acute/drug therapy , Risk Assessment , Severity of Illness Index , Treatment OutcomeABSTRACT
Keloid disorder (KD) is a fibroproliferative ailment of the cutaneous connective tissue secondary to dysregulation in various skin repair and healing processes. This disorder is characterized by excess collagen and/or glycoprotein depositions in the dermis. Age of onset of KD is not well documented. Based on clinical observations, various authors have reported the onset of KD to be between the ages of 10 and 30 years. We report on an African American female who developed bilateral auricular keloids at the age of 9 months. To our knowledge, this is the youngest age at which a patient has been documented to have developed KD.