[Long-term persistence of coxsackieviruses in familial foci of infectious myocarditis patients]. / Dlitel'noe sokhranenie virusov Koksaki v semeinykh ochagakh v okruzhenii bol'nykh infektsionnym miokarditom.

Numerous examinations during 12-36 months of 16 children suffering from myocarditis and their 37 relatives revealed long-term persistence of Coxsackie A13/A18 viruses in the familial foci of infection in 13 cases. In addition, 9 families were found to have foci of Coxsackie B virus infection of which 2 were also persistent (Coxsackie B1 and B3) and 7 transitory. In 8 families, Coxsackie B viruses circulated simultaneously with Coxsackie A13/A18.

[Correlation of cephalosporin C synthesis and proteolytic enzymes in a differentiating culture of Acremonium chrysogenum (Cephalosporum acremonium) mutants]. / Korreliatsiia sinteza tsefalosporina C i proteoliticheskikh fermentov v differentsiruiushcheisia kul'ture mutantov Acremonium chrysogenum (Cephalosporium acremonium).

The effect of the growth conditions and composition of the nutrient medium on the synthesis of cephalosporin C, alkaline exoproteases and cell differentiation was studied in various strains of Acremonium chrysogenum. It was observed that the changes in the above processes occurred simultaneously and depended on the aeration rate, temperature, illumination level and concentrations of methionine and soybean meal. Close correlation between the synthesis of alkaline exoproteases, cephalosporin C and formation of secondary structures in the strains of A. chrysogenum was shown.

[Persistence of Coxsackie A13 virus in the families of children ill with rheumocarditis]. / Persistentsiiia virusa Koksaki A13 v semiakh bol'nykh revmokarditom detei.

Virological and clinico-instrumental examinations were carried out three times during one year in 13 patients with rheumatic carditis and 34 of their relatives from 13 families. Besides, probands from 5 families had been examined 1-3 years before this study during treatment for rheumocarditis. Among 62 virus strains isolated from feces, blood, and nasopharyngeal washings in the family foci 40 were Coxsackie A13, 12: Coxsackie B1, B2, B5; 10 viruses were not identified. Coxsackie A13 virus was isolated from probands, siblings and parents in 11 out of 13 families. Virus-neutralizing antibodies to it were demonstrated in the great majority of probands and relatives, including those families where no virus had been isolated. Coxsackie A13 virus and antibodies to it were shown to persist throughout the observation period in most families.

[Regulation of alkaline exoprotease and cephalosporin C synthesis in Acremonium chrysogenum by different carbon and nitrogen sources]. / Reguliatsiia razlichnymi istochnikami ugleroda i azota sinteza shchelochnykh ékzoproteaz i tsefalosporina C u Acremonium chrysogenum.

The synthesis of exoproteases and cephalosporin C in Acremonium chrysogenum is repressed by easily assimilated forms of nitrogen and carbon according to the type of nitrogen metabolism repression and catabolism inhibition. Glucose and ammonium salts inhibited the mycelium fragmentation and prevented formation of conidia. Amino acids had a diverse effect on the synthesis of the proteases and antibiotic. Methionine played the role of an inductor of the synthesis of alkaline exoproteases, cephalosporin C and the mycelium fragmentation into arthrospores.

[Variability of a Cephalosporium acremonium culture for 2 quantitative traits: antibiotic formation and proteolytic activity]. / Izmenchivost' kul'tury Cephalosporium acremonium po dvum kolichestvennym priznakam--antibiotikoobrazovaniiu i proteoliticheskoi aktivnosti.

Exposure of Cephalosporium acremonium, strain 1435, to N-nitrozo-N-methylbiuret resulted in a changed variation coefficient with respect to two quantitative features--the antibiotic production and proteolytic activity. Correlation between the variation coefficient and mutagen exposure time was different for every feature. Positive correlation was found in variation with respect to the antibiotic production and proteolytic activity in populations of various Cephalosporium acremonium strains chosen with regard to one or two of the above features. The level and form of the correlation in variation of the above features in populations changed during selection. Selection according to the two quantitative features resulted in an increased correlation coefficient.

[Experimental study of Coxsackie-streptococcal infection]. / Eksperimental'noe izuchenie koksaki-streptokokkovoi infektsii.

The pathological process due to Coxsackie A18 virus and hemolytic streptococcus infection was studied in adult white mice. Their synergistic effect was established as manifested by longer periods of virus detection in the blood and heart and the detection of the streptococcus in animals infected with an 8-fold lower dose. In cases of combined infection, signs of dystrophy, destruction and proliferation developed in the myocardium reaching the highest intensity when the virus and the microbe had been inoculated simultaneously.

[Lethal and mutagenic action of nitrosomethylbiuret on a culture of the mycophilic fungus, Didymocladium ternatum]. / Letal'noe i mutagennoe deistvie nitrozometilbiureta na kul'turu mikofil'nogo griba Didymocladium ternatum

The effect of N-nitrozo-N-methylbiuret (NMB) on various features of Didymocladium ternatum, an organism producing termatin was studied. It was found that the lethal effect of NMB depended on the exposure time, prolongation of which resulted in increased numbers of the plus variants, morphological mutations and reverses into the populations. Variants possessing 8 times higher activity as compared to the initial culture were obtained as a result of selection of active variants.