ABSTRACT
Objective:To explore the survival status of rectal cancer patients with liver metastasis after receiving different treatments and its influencing factors.Methods:The clinicopathological characteristics, treatment methods and survival of 211 rectal cancer patients with liver metastasis who received different treatments in Shanxi Provincial Cancer Hospital from January 2012 to December 2016 were retrospectively analyzed. Cox proportional hazards regression model was used to analyze the related factors affecting the prognosis of patients.Results:The median overall survival (OS) time of 211 rectal cancer patients with liver metastasis was 19 months (1-115 months), and the 1-, 3- and 5-year OS rates were 66%, 22% and 10%. The OS of rectal cancer patients with metachronous liver metastasis was better than that of rectal cancer patients with simultaneous liver metastasis ( χ2 = 17.225, P < 0.01). The OS of patients with primary tumor resection was better than that of patients without primary tumor resection ( χ2 = 69.54, P < 0.01). Among patients with primary tumor resection, the OS of patients with untreated liver metastasis was worse than that of patients with interventional treatment of liver metastasis ( χ2 = 7.311, P = 0.007). Among the patients without primary tumor resection, the OS of patients with chemotherapy alone was better than that of untreated patients ( χ2 = 4.123, P = 0.042). The OS of patients with primary tumor resection and untreated liver metastasis and patients with primary tumor resection and liver metastasis intervention therapy was better than that of patients with chemotherapy alone (both P < 0.01). The results of Cox regression analysis showed that the differentiation degree of primary tumor, liver metastasis and carbohydrate antigen 199 level at diagnosis were independent factors influencing the survival of rectal cancer patients with liver metastasis (all P < 0.01). Conclusion:For patients with diagnosed rectal cancer, even if there is liver metastasis before surgery, active surgical resection of the primary tumor and local treatment of liver metastasis can still improve the survival.
ABSTRACT
Plant grafting is a well-known activity in orchards, greenhouses and vineyards gardens. However, low survival rate still limits the promotion of grafting and breeding of improved varieties. We report on polymeric fibers, obtained through coaxial electrospun, as carriers for the sustained release of drugs to heal wounds in plants. The CA-PU co-electrospun fibers show a rather uniform diameter, a smooth and hydrophilic surface. As long as 10days of sustained drugs release meets with the physiological requirement of plant grafting. The callus toxicity test shows that the CA-PU fibers are not toxic for plant cells. We show that loading the core of CA-PU fibers with 6-Benzylaminopurine (6-BA), a first-generation synthetic cytokinin that elicits plant growth and development, results in fibers that can efficiently promote the healing of plant wounds, thereby significantly improving the grafting survival rate.
