From pseudocholinesterase to human immunodeficiency virus.

Pseudocholinesterase is a protein for which no function exists in mammals including human beings. To date, no substrate has been identified for this 'enzyme'. Involvement of this protein in the aetiopathogenesis of many diseases, such as hyperlipoproteinaemia, is still actively debated. Here, we propose a theoretical method to immobilize pseudocholinesterase in hepatocytes using antibody bound to liposomes. Conceptually, this approach will have widespread application, especially in blocking human immunodeficiency virus replication in vivo.