ABSTRACT
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck region, especially among those of Chinese origin. NPC has multifactorial aetiologies including genetic susceptibility, consumption of food with high salt content, and the Epstein-Barr virus. The primary tumour usually arises from the lateral walls of the nasopharynx and is characterized by a rich sub-mucosal lymphatic structure, often leading to cervical lymph node metastasis. Distant metastasis has been recognized to be a major cause of treatment failure in patients with nasopharyngeal carcinoma. Bone, liver and lung are the most frequent sites of NPC metastases.
ABSTRACT
Research has shown a decrease in femoral bone-to-implant contact in rats with uncontrolled diabetes. The present study aimed to test the hypothesis that this decrease may be the result of a decreased mineral apposition rate. In 20 normal and 20 diabetic rats, a titanium implant was inserted into the tooth extraction socket immediately after the right maxillary molars were extracted. There was a significantly reduced mineral apposition rate in the diabetic rats compared with the normal rats (P = .0001), but no difference between rats sacrificed at 20 and 40 days (P = .297). The results suggest that implant insertion immediately following tooth extraction in patients with poorly controlled diabetes is contraindicated.
