Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Org Lett ; 24(42): 7812-7816, 2022 Oct 28.
Article in English | MEDLINE | ID: mdl-36222500

ABSTRACT

The first enantioselective total synthesis of aryltetralin lignan acetals, (-)-formosanol, (+)-tsugacetal, (+)-methyl ß-conidendral, and their enantiomers have been accomplished on the basis of the Pd-catalyzed asymmetric allylic cycloaddition as a key step. Six stereoisomers of the lignan acetals have been synthesized via a 7-8 step sequence in up to 14% overall yield. The in vitro cytotoxicity against several cancer cells has preliminarily been examined for the obtained six stereoisomers of lignan acetals.


Subject(s)
Acetals , Lignans , Cycloaddition Reaction , Lignans/pharmacology , Stereoisomerism
SELECTION OF CITATIONS
SEARCH DETAIL
...