Lesion detection in women breast's dynamic contrast-enhanced magnetic resonance imaging using deep learning.

Breast cancer is one of the most common cancers in women and the second foremost cause of cancer death in women after lung cancer. Recent technological advances in breast cancer treatment offer hope to millions of women in the world. Segmentation of the breast's Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is one of the necessary tasks in the diagnosis and detection of breast cancer. Currently, a popular deep learning model, U-Net is extensively used in biomedical image segmentation. This article aims to advance the state of the art and conduct a more in-depth analysis with a focus on the use of various U-Net models in lesion detection in women's breast DCE-MRI. In this article, we perform an empirical study of the effectiveness and efficiency of U-Net and its derived deep learning models including ResUNet, Dense UNet, DUNet, Attention U-Net, UNet++, MultiResUNet, RAUNet, Inception U-Net and U-Net GAN for lesion detection in breast DCE-MRI. All the models are applied to the benchmarked 100 Sagittal T2-Weighted fat-suppressed DCE-MRI slices of 20 patients and their performance is compared. Also, a comparative study has been conducted with V-Net, W-Net, and DeepLabV3+. Non-parametric statistical test Wilcoxon Signed Rank Test is used to analyze the significance of the quantitative results. Furthermore, Multi-Criteria Decision Analysis (MCDA) is used to evaluate overall performance focused on accuracy, precision, sensitivity, F[Formula: see text]-score, specificity, Geometric-Mean, DSC, and false-positive rate. The RAUNet segmentation model achieved a high accuracy of 99.76%, sensitivity of 85.04%, precision of 90.21%, and Dice Similarity Coefficient (DSC) of 85.04% whereas ResNet achieved 99.62% accuracy, 62.26% sensitivity, 99.56% precision, and 72.86% DSC. ResUNet is found to be the most effective model based on MCDA. On the other hand, U-Net GAN takes the least computational time to perform the segmentation task. Both quantitative and qualitative results demonstrate that the ResNet model performs better than other models in segmenting the images and lesion detection, though computational time in achieving the objectives varies.

Identification of breast lesion through integrated study of gorilla troops optimization and rotation-based learning from MRI images.

Breast cancer has emerged as the most life-threatening disease among women around the world. Early detection and treatment of breast cancer are thought to reduce the need for surgery and boost the survival rate. The Magnetic Resonance Imaging (MRI) segmentation techniques for breast cancer diagnosis are investigated in this article. Kapur's entropy-based multilevel thresholding is used in this study to determine optimal values for breast DCE-MRI lesion segmentation using Gorilla Troops Optimization (GTO). An improved GTO, is developed by incorporating Rotational opposition based-learning (RBL) into GTO called (GTORBL) and applied it to the same problem. The proposed approaches are tested on 20 patients' T2 Weighted Sagittal (T2 WS) DCE-MRI 100 slices. The proposed approaches are compared with Tunicate Swarm Algorithm (TSA), Particle Swarm Optimization (PSO), Arithmetic Optimization Algorithm (AOA), Slime Mould Algorithm (SMA), Multi-verse Optimization (MVO), Hidden Markov Random Field (HMRF), Improved Markov Random Field (IMRF), and Conventional Markov Random Field (CMRF). The Dice Similarity Coefficient (DSC), sensitivity, and accuracy of the proposed GTO-based approach is achieved [Formula: see text], [Formula: see text], and [Formula: see text] respectively. Another proposed GTORBL-based segmentation method achieves accuracy values of [Formula: see text] , sensitivity of [Formula: see text] , and DSC of [Formula: see text]. The one-way ANOVA test followed by Tukey HSD and Wilcoxon Signed Rank Test are used to examine the results. Furthermore, Multi-Criteria Decision Making is used to evaluate overall performance focused on sensitivity, accuracy, false-positive rate, precision, specificity, [Formula: see text]-score, Geometric-Mean, and DSC. According to both quantitative and qualitative findings, the proposed strategies outperform other compared methodologies.

A novel watermarking scheme for medical image using support vector machine and lifting wavelet transform.

Digital image watermarking has become a valuable tool for preventing unauthorized use and alteration of digital images due to technological advancements. A fundamental difficulty in digital image watermarking is to provide resilience against geometrical assault while retaining a sufficient degree of imperceptibility and security. This study presents an efficient authentication scheme for digital image watermarking on medical images benefiting from both techniques: Support Vector Machine (SVM) and Lifting Wavelet Transform (LWT). In this article, we use two strategies, where SVM is used first to separate the Region of Interest (ROI) from the Non-Region of Interest (NROI) in the medical image. Then LWT is applied to embed watermark information within the NROI part of the medical image (Cover Image). Moreover, we have applied a shared secret key to enhancing the robustness of the proposed scheme. The method is tested on an extensive image database to see how it performs under different situations. The research looked into the various experimental analyses to establish the acceptability of the existing scheme. The simulation is performed to measure the imperceptibility and robustness using various evaluation metrics.

A novel steganographic technique for medical image using SVM and IWT.

This study presents an efficient authentication scheme for digital image steganography on medical images benefiting from the combination of both techniques: Support Vector Machine (SVM) and Integer Wavelet Transform (IWT). We use two different strategies in this paper, where SVM is used first to separate the Region of Interest (ROI) from Non-Region of Interest (NROI) in the medical image. Then IWT is applied to embed secret information within the NROI part of the medical image (Cover Image). Moreover, we have applied a circular array and a shared secret key to enhance the robustness of the proposed scheme. The research looked into the various experimental analyses to establish the acceptability of the existing scheme. The simulation is performed to measure the imperceptibility using Peak Signal to Noise Ratio (PSNR) and to test the robustness using the Structural Similarity Index Measure (SSIM). The experimental result shows good imperceptibility with a PSNR of 64 dB and better robustness with a SSIM of 0.96 for the proposed steganographic scheme.

Subtyping and grading of lower-grade gliomas using integrated feature selection and support vector machine.

Classifying lower-grade gliomas (LGGs) is a crucial step for accurate therapeutic intervention. The histopathological classification of various subtypes of LGG, including astrocytoma, oligodendroglioma and oligoastrocytoma, suffers from intraobserver and interobserver variability leading to inaccurate classification and greater risk to patient health. We designed an efficient machine learning-based classification framework to diagnose LGG subtypes and grades using transcriptome data. First, we developed an integrated feature selection method based on correlation and support vector machine (SVM) recursive feature elimination. Then, implementation of the SVM classifier achieved superior accuracy compared with other machine learning frameworks. Most importantly, we found that the accuracy of subtype classification is always high (>90%) in a specific grade rather than in mixed grade (~80%) cancer. Differential co-expression analysis revealed higher heterogeneity in mixed grade cancer, resulting in reduced prediction accuracy. Our findings suggest that it is necessary to identify cancer grades and subtypes to attain a higher classification accuracy. Our six-class classification model efficiently predicts the grades and subtypes with an average accuracy of 91% (±0.02). Furthermore, we identify several predictive biomarkers using co-expression, gene set enrichment and survival analysis, indicating our framework is biologically interpretable and can potentially support the clinician.

A Deep Learning-Based Framework for Supporting Clinical Diagnosis of Glioblastoma Subtypes.

Understanding molecular features that facilitate aggressive phenotypes in glioblastoma multiforme (GBM) remains a major clinical challenge. Accurate diagnosis of GBM subtypes, namely classical, proneural, and mesenchymal, and identification of specific molecular features are crucial for clinicians for systematic treatment. We develop a biologically interpretable and highly efficient deep learning framework based on a convolutional neural network for subtype identification. The classifiers were generated from high-throughput data of different molecular levels, i.e., transcriptome and methylome. Furthermore, an integrated subsystem of transcriptome and methylome data was also used to build the biologically relevant model. Our results show that deep learning model outperforms the traditional machine learning algorithms. Furthermore, to evaluate the biological and clinical applicability of the classification, we performed weighted gene correlation network analysis, gene set enrichment, and survival analysis of the feature genes. We identified the genotype-phenotype relationship of GBM subtypes and the subtype-specific predictive biomarkers for potential diagnosis and treatment.