[Modification of 3-methylcholanthrene-induced blastomogenesis in BALB/c mice by using the subcellular components of Bac. megaterium H]. / Modifikatsiia blastomogeneza, indutsirovannogo 3-metilkholantrenom u myshei BALB/c, pri pomoshchi subkletochnykh komponentov Bac. megaterium H.

It is shown that the cytoplasm of Bac. megaterium H possessing the antigenic affinity with the malignant tumour cells, being injected 7 days before the 3-methylcholanthrene injection promotes intensification of its blastomogenic effect, reduces both the period of tumour appearance and longevity of the tumour-bearing animals. On the contrary the cell wall preparation under the similar conditions, produces a therapeutic effect. An assumption is advanced that the effect of these preparations is associated with their different influence on the immune system.

[Effect of Bac. megaterium H on tumor induction by methylcholanthrene]. / Vliianie Bac. megaterium H na induktsiiu opukholei metilkholantrenom.

It is shown that Bac megaterium H which has cross-reacting antigens with malignant tumour tissues may influence the time of appearance and growth of tumours, induced by 20-methylcholanthrene in BALB/c mice. The strengthening of tumour growth rate was most distinctly displayed if Bac. megaterium H was injected once 7 days before the methylcholanthrene inoculation.

[Possible role of Bac. megaterium H antigens common with tumor antigens in the increase of the antitumor activity of lymphocytes]. / O vozmozhnoi roli obshchikh s opukholevymi antigenov mikrobnoi kul'tury Bac. megaterium H v povyshenii protivoopukholevoi aktivnosti limfotsitov.

The antitumour cytotoxic activity of lymphocytes is shown to increase both with inoculation of antigens contained in tumour cells and under the influence of microbial Bac. megaterium H., culture, its ultrasonic homogenate, cell walls and cytoplasmic preparation. Certain cytoplasmic fractions of Bac. megaterium H, like other microbial and tissue antigens having no similarity with tumour cells, did not produce such an effect. An assumption is advanced that the increase in the antitumour cytotoxicity of lymphocytes under the influence of Bac. megaterium H is due to the cross-reacting antigens contained in the microbial cell and blastoma tissue.