ABSTRACT
With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between chitosan (CS) and Eudragit L100 (L100) or Eudragit L100-55 (L100-55) was investigated at pH 6.0, using elementary analysis. The interaction or binding ratio of a unit molecule of CS with Eudragit L copolymers depends on the molecular weight of CS, and changes from 1:0.85 to 1:1.22 (1.17Subject(s)
Acrylic Resins/chemistry
, Anti-Inflammatory Agents, Non-Steroidal/chemistry
, Chitosan/chemistry
, Diclofenac/chemistry
, Drug Carriers
, Polymethacrylic Acids/chemistry
, Administration, Oral
, Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
, Chemistry, Pharmaceutical
, Delayed-Action Preparations
, Diclofenac/administration & dosage
, Hydrogen-Ion Concentration
, Kinetics
, Molecular Structure
, Molecular Weight
, Solubility
, Tablets
, Technology, Pharmaceutical/methods
, Water/chemistry
