Subject(s)
Carotid Arteries/physiopathology , Carotid Stenosis/physiopathology , Glaucoma, Open-Angle/physiopathology , Ophthalmic Artery/physiopathology , Visual Acuity , Aged , Aged, 80 and over , Blood Flow Velocity , Carotid Arteries/diagnostic imaging , Carotid Stenosis/complications , Carotid Stenosis/diagnostic imaging , Electroretinography , Evoked Potentials, Visual , Follow-Up Studies , Glaucoma, Open-Angle/etiology , Humans , Intraocular Pressure , Middle Aged , Ophthalmic Artery/diagnostic imaging , Ultrasonography, Doppler , Visual Field TestsSubject(s)
Carotid Stenosis/physiopathology , Cerebrovascular Circulation , Ophthalmic Artery/physiopathology , Aged , Aged, 80 and over , Blood Flow Velocity , Electroretinography , Evoked Potentials, Visual , Follow-Up Studies , Humans , Image Processing, Computer-Assisted , Middle Aged , Ophthalmic Artery/diagnostic imaging , Ultrasonography, Doppler, Color , Visual Field TestsSubject(s)
Choroid/blood supply , Ciliary Body/physiopathology , Glaucoma, Open-Angle/surgery , Retinal Artery/physiopathology , Trabeculectomy , Ultrasonography, Doppler, Color , Blood Flow Velocity , Chronic Disease , Ciliary Body/diagnostic imaging , Glaucoma, Open-Angle/diagnostic imaging , Glaucoma, Open-Angle/physiopathology , Humans , Intraocular Pressure , Retinal Artery/diagnostic imaging , Vascular ResistanceSubject(s)
Electroretinography , Glaucoma, Open-Angle/diagnosis , Retina/physiology , Chronic Disease , Evaluation Studies as Topic , Female , Glaucoma, Open-Angle/physiopathology , Humans , Image Processing, Computer-Assisted , Intraocular Pressure , Male , Middle Aged , Visual Acuity , Visual Field Tests , Visual FieldsABSTRACT
BACKGROUND: The vascular factor is becoming increasingly important in the pathogenesis of primary open-angle glaucoma. Ocular hypotonia, which is indubitably a risk factor in the development of glaucoma, cannot be regarded as the sole pathogenic factor. Clinical experience leaves no doubt that some patients tolerate a high IOP for prolonged periods of time without ocular damage. In others, however, severe glaucoma-related lesions result from slight hypertonia or critically low pressure. METHODS: The authors analyze the general factors which influence ocular blood flow and increase the deleterious effect of ocular hypertonia, and report results relating to the hemodynamic status of a group of glaucoma patients prior to and after one year of therapy with beta-blockers. The results are analyzed and discussed.
Subject(s)
Eye/blood supply , Glaucoma, Open-Angle/physiopathology , Intraocular Pressure/physiology , Adrenergic beta-Antagonists/therapeutic use , Blood Flow Velocity/drug effects , Blood Flow Velocity/physiology , Blood Pressure/drug effects , Blood Pressure/physiology , Follow-Up Studies , Glaucoma, Open-Angle/drug therapy , Homeostasis/drug effects , Homeostasis/physiology , Humans , Intraocular Pressure/drug effects , Parasympathomimetics/therapeutic use , Regional Blood Flow/drug effects , Regional Blood Flow/physiology , Signal Processing, Computer-Assisted/instrumentation , Tonometry, Ocular/instrumentationABSTRACT
In the past several years the effect of longterm glaucoma therapy on ocular hemodynamics has taken on increased interest. This interest has been sparked by studies demonstrating differential effects of various beta-blockers on visual function, and the possible contributory role of ocular blood flow. In the present study, the pulsatile ocular blood flow (POBF), as derived by the Langham OBF system, was measured prior to treatment and then tracked throughout a one-year period of beta-blocker therapy (betaxolol 0.5% or timolol 0.5%) in 25 glaucoma patients. Results of the two treatments were compared, and indicated that, whereas both betaxolol- and timolol-treated patients had similar significant reductions in the IOP, the effect of the two treatments on the POBF differed. In timolol-treated patients, the POBF decreased significantly over the 12-month observation period, whereas in betaxolol-treated patients it remained stable.
