ABSTRACT
In a double-blind controlled comparison that lasted eight weeks, tablets of zinc sulfate monohydrate, 411 mg total daily dosage, and a lactose placebo were administered orally to 22 male subjects with moderate acne. At the same time, levels of zinc were determined in serum and urine. There were no statistically significant differences in the lesion counts (papules, pustules, open comedones, and closed comedones) in the zinc-treated and lactose-treated cases, despite evidence in serum and urine of absorption of zinc. The data from this study indicate that oral zinc therapy has no early clinical effect on male patients with moderate acne.
Subject(s)
Acne Vulgaris/drug therapy , Zinc/administration & dosage , Administration, Oral , Adolescent , Adult , Clinical Trials as Topic , Double-Blind Method , Humans , Intestinal Absorption , Male , Placebos , Zinc/metabolism , Zinc/therapeutic useABSTRACT
Although any drug may cause any dermatitis, it is possible to categorize a relatively few types of dermatitis and a relatively small number of drugs in such a way as to afford a practical approach to a sometimes confusing problem. These problems are generally clinical ones not requiring laboratory work and an experienced clinician will probably be able to manage most of these cases without extensive consultations.
Subject(s)
Drug Eruptions/etiology , Drug Eruptions/classification , Female , Humans , Male , Poisoning/complicationsABSTRACT
Fournier's gangrene is a rare, fulminant, though generally localizaed disease of the scrotum and penis. Three cases are presented in which the sexual practices of the patients may have played a role in the etiology. Hospitalization, parenteral antibiotics, and appropriate surgical treatment are required.
