Effect of microneedle combined with Lauromacrogol on skin capillary network: experimental study / 中华整形外科杂志

<p><b>OBJECTIVE</b>To explore the effect of microneedle combined with Lauromacrogol on skin capillary network.</p><p><b>METHODS</b>24 male Leghone (1.5-2.0 kg in weight) were randomly divided into three groups as group A (microneedle combined with Lauromacrogol), B (microneedle combined with physiological saline) , and C(control). The cockscombs were treated. The specimens were taken on the 7th, 14th, 21th , and 28th day postoperatively. HE staining, immunohistochemical staining and special staining were performed for study of the number of capillary and collagen I/III , as well as elastic fibers.</p><p><b>RESULTS</b>The color of cockscombs in group A became lightening after treatment. The number of capillary decreased as showing by HE staining. The collagen I and III in group B was significantly different from that in group A and C (P < 0.05). Special staining showed proliferation of elastic fibers in group B.</p><p><b>CONCLUSIONS</b>It indicates that microneedle combined with Lauromacrogol could effectively reduce the capillary in cockscomb without any tissue fibrosis. Microneedle can stimulate the proliferation of elastic fiber, so as to improve the skin ageing process.</p>

Efficay of skin roller pin combined with medication on cutaneous capillary hemangioma: an experimental study / 中华医学美学美容杂志

Objective To investigate the role of the skin needle combined with different drugs in the treatment of capillary hemangioma,providing a theoretical basis for clinical treatment.Methods 50 Lai Henry chickens were randomly divided into five groups,each group of 10.Taking the comb as an animal model of capillary hemangioma of the skin,we used skin needle combined with different drugs onto the comb:Group A:bleomycin,B:triamcinolone acetonide,C:triamcinolone acetonide combined with bleomycin,D:saline group,and E.normal comb as a blank control group.We observed the changes of the comb and pathological changes,the number of capillaries under microscope in 1 d,7 d,14 d,21 d,and 28 d respectively.Results The color of the comb in each group gradually became lighter in different degrees,the number of capillaries reduced,the most significantly in group C,and most less change in group D.Conclusions Tumbling of the skin needle and drugs can effectively reduce the number of capillaries alone,and both effects can be cumulative.The best efficacy has been achieved with skin needle combined with bleomycin.