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Protecting the bladder from cyclophosphamide with mesna.

Finn, G P; Sidau, B; Shaw, I C.

N Engl J Med ; 314(1): 61, 1986 Jan 02.

Article in English | MEDLINE | ID: mdl-3079620

Subject(s)

Cyclophosphamide/adverse effects , Mercaptoethanol/analogs & derivatives , Mesna/therapeutic use , Urinary Bladder/drug effects , Humans , Sulfhydryl Compounds/urine

Determination of sodium 2-mercaptoethanesulphonate by high-performance liquid chromatography using post-column reaction colorimetry or electrochemical detection.

Sidau, B; Shaw, I C.

J Chromatogr ; 311(1): 234-8, 1984 Nov 09.

Article in English | MEDLINE | ID: mdl-6440899

Subject(s)

Mercaptoethanol/analogs & derivatives , Mesna/analysis , Chromatography, High Pressure Liquid/methods , Colorimetry , Electrochemistry , Humans , Mesna/urine

Decreased plasma half-life of cyclophosphamide during repeated high-dose administration.

Graham, M I; Shaw, I C; Souhami, R L; Sidau, B; Harper, P G; McLean, A E.

Cancer Chemother Pharmacol ; 10(3): 192-3, 1983.

Article in English | MEDLINE | ID: mdl-6861264

ABSTRACT

Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide by gas liquid chromatography. The plasma half-lives (t 1/2) and volumes of distribution (V D) were calculated for each of the treatment days; t 1/2 was found to decrease with subsequent doses whereas V D was not significantly changed.

Subject(s)

Cyclophosphamide/blood , Lung Neoplasms/blood , Ovarian Neoplasms/blood , Cyclophosphamide/administration & dosage , Dose-Response Relationship, Drug , Female , Half-Life , Humans , Kinetics , Lung Neoplasms/drug therapy , Male , Ovarian Neoplasms/drug therapy

Rat liver changes after subchronic exposition to polychlorinated biphenyls (PCB) of low chlorine content.

Schmoldt, A; Altenähr, E; Grote, W; Dammann, H G; Sidau, B; Benthe, H F.

Arch Toxicol ; 37(3): 203-17, 1977 Jul 19.

Article in English | MEDLINE | ID: mdl-409375

Subject(s)

Liver/drug effects , Polychlorinated Biphenyls/pharmacology , Animals , Body Weight/drug effects , Diet , Lipid Metabolism , Liver/anatomy & histology , Liver/metabolism , Liver Function Tests , Male , Microsomes, Liver/drug effects , Microsomes, Liver/enzymology , Organ Size/drug effects , Polychlorinated Biphenyls/metabolism , Porphyrins/metabolism , Rats , Structure-Activity Relationship , Time Factors

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